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Advances in Experimental Medicine and Biology

Proteostasis and Disease

From Basic Mechanisms to Clinics

Herausgeber: Barrio, Rosa, Sutherland, James D., Rodriguez, Manuel S. (Eds.)

Vorschau
  • Discusses protein homeostasis in the context of cancer, neurodegeneration, inflammation and infection
  • Provides a state-of-the-art overview and guidance for future research
  • Highlights the role of proteostasis in cellular development and physiology
  • Presents essential information for clinicians and researchers as well as students new to the field
  • Written by members of the European network PROTEOSTASIS
Weitere Vorteile

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  • ISBN 978-3-030-38266-7
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Hardcover 160,49 €
Preis für Deutschland (Brutto)
  • ISBN 978-3-030-38265-0
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Über dieses Buch

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. 

Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.


Über den Autor

Rosa Barrio obtained her PhD in the Centre of Molecular Biology Severo Ochoa (Madrid, Spain) on the study of ubiquitin genes in Drosophila. Since then, she was interested on the effect of ubiquitin-like molecules on relevant transcription factors involved in organismal development and physiology. After her postdoctoral training at European Molecular Biology Laboratory (Heidelberg, Germany), she is a principal investigator in the Functional Genomics Unit of CIC bioGUNE (Derio, Spain) since December 2004. Using Drosophila as a model system, her laboratory unveiled the role of SUMOylation in vivo in the processes of steroidogenesis through the regulation of the Steroidogenic Factor 1, and development through the regulation of the Spalt-like factors (SALL) and ciliogenesis. The laboratory developed technology for the study posttranslational modifications by members of the ubiquitin family, and apply this technology for the analysis of the ubiquitin code.

Jim Sutherland is a developmental/cellular biologist studying protein homeostasis regulation in the primary cilia. His doctoral research on USP/DHR38 heterodimers and the Drosophila ecdysone response was completed at Harvard University and EMBL under the supervision of Dr. Fotis Kafatos. His post-doctoral research was focused on the functional analysis of profilin and regulation of the actin cytoskeleton in the mouse (Witke Group, EMBL Rome) and on the role of TES in cellular adhesion (Way Group, Cancer Research UK, London). In 2005, he joined the Cooperative Research Centre bioGUNE (CIC bioGUNE) as a staff researcher. He develops novel tools for studying modifications by ubiquitin and ubiquitin-like proteins. These are applied towards understanding primary cilia formation and function, with special focus on Townes Brock Syndrome, a rare ciliopathy caused by SALL1 mutations and characterized by developmental defects and kidney dysfunction.

Manuel S Rodriguez obtained his PhD degree in microbiology at Pasteur Institute (Paris, France). Early in his carrier he became interested in the role of ubiquitin family members in the regulation of critical cellular factors such as those involved in the immune response, apoptosis or oncogenesis. He was particularly intrigued by the role of ubiquitin-like proteins (UbLs) in the regulation of protein homeostasis in situations when two or more members of this family were acting on the same protein or pathways. Some of his work was oriented to study the regulation of NF-kB and the tumour suppressor p53. More recently his efforts have been oriented to the study of the crosstalk between the ubiquitin proteasome and autophagy-Lysosome systems. His group became particularly interested in a selective autophagy mechanism named proteaphagy that appears to regulate the pool of 26S proteasome in response to proteasome inhibition. Among other contributions he developed methods to study post-modification events and its functional consequences. Including ubiquitin capturing systems (named TUBEs) based in the tandem disposition of ubiquitin binding domains and a version of SUMO-traps that have been used to study the response of the cell to distinct stimuli/infections. Manuel S. Rodriguez is currently a group leader at the Institute for advanced technologies in life sciences (ITAV) from the CNRS (Toulouse, France). 

Inhaltsverzeichnis (15 Kapitel)

Inhaltsverzeichnis (15 Kapitel)

Dieses Buch kaufen

eBook 117,69 €
Preis für Deutschland (Brutto)
  • ISBN 978-3-030-38266-7
  • Versehen mit digitalem Wasserzeichen, DRM-frei
  • Erhältliche Formate: EPUB, PDF
  • eBooks sind auf allen Endgeräten nutzbar
  • Sofortiger eBook Download nach Kauf
Hardcover 160,49 €
Preis für Deutschland (Brutto)
  • ISBN 978-3-030-38265-0
  • Kostenfreier Versand für Individualkunden weltweit
  • Kostenloser Sofortzugriff* auf die eBook-Version bei jeder Buchbestellung
  • Gewöhnlich versandfertig in 3-5 Werktagen.
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Bibliografische Information

Bibliographic Information
Buchtitel
Proteostasis and Disease
Buchuntertitel
From Basic Mechanisms to Clinics
Herausgeber
  • Rosa Barrio
  • James D. Sutherland
  • Manuel S. Rodriguez
Titel der Buchreihe
Advances in Experimental Medicine and Biology
Buchreihen Band
1233
Copyright
2020
Verlag
Springer International Publishing
Copyright Inhaber
Springer Nature Switzerland AG
eBook ISBN
978-3-030-38266-7
DOI
10.1007/978-3-030-38266-7
Hardcover ISBN
978-3-030-38265-0
Buchreihen ISSN
0065-2598
Auflage
1
Seitenzahl
XII, 348
Anzahl der Bilder
18 schwarz-weiß Abbildungen, 24 Abbildungen in Farbe
Themen

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