Contemporary Bone Marrow Transplantation

1. Front Matter

   Pages i-xvii

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. History of Bone Marrow Transplantation

      • Emmanouil Nikolousis, T. Sakia, Claire Horgan, Maria Ahmed

      Pages 3-26

3. Biology of Bone Marrow Transplantation

   1. Front Matter

      Pages 27-27

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   2. Stem Cell Biology in Bone Marrow Transplantation

      • Karen-Sue B. Carlson, Joshua Morris, Lauryn P. Cross, Sridhar Rao

      Pages 29-42

   3. HLA in Hematopoietic Stem Cell Transplantation

      • Deepak Kumar Mishra, Saheli Banerjee, Neeraj Arora, Mayur Parihar

      Pages 43-54

   4. Biology of Graft-Versus-Host Disease

      • Igor Novitzky-Basso, Auro Viswabandya

      Pages 55-73

   5. Chimerism in Hematopoietic Stem Cell Transplantation

      • Deepak Kumar Mishra, Kunjal Ramanbhai Patel, Mayur Parihar, Ashay Karpe

      Pages 75-98

   6. HSCT in Malignancies

      • Maria Queralt Salas, Auro Viswabandya

      Pages 99-114

   7. HSCT in Benign Hematological Disorders

      • Suhag Parikh, Shanmuganathan Chandrakasan

      Pages 115-163

   8. Hemopoietic Stem Cell Transplant for Non-hematological Disorders

      • Rubiya Nadaf, Jane Kinsella, Robert Wynn

      Pages 165-184

4. Bone Marrow Transplantation: The Procedure

   1. Front Matter

      Pages 185-185

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   2. Allogeneic Transplant Overview and Matched Related Donor Transplant

      • Navneet S. Majhail

      Pages 187-221

   3. Haploidentical Transplantation: Challenges and Solutions

      • Suparno Chakrabarti, Sarita Rani Jaiswal

      Pages 223-263

   4. Unrelated Donor Allogeneic Transplant

      • Saurabh Chhabra, Parameswaran Hari

      Pages 265-283

   5. Umbilical Cord Blood Transplantation

      • Revathi Raj

      Pages 285-295

   6. Autologous Bone Marrow Transplant

      • Lalit Kumar, Raja Pramanik

      Pages 297-313

   7. Transplant Pharmacology and Conditioning Therapy

      • Ashish Bajel

      Pages 315-346

   8. Total Body Irradiation in Stem Cell Transplant

      • Rimpa Achari, Abhijit Das, Anurupa Mahata

      Pages 347-364

   9. Graft Versus Host Disease: Management of Acute and Chronic Disease

      • Albert C. Yeh, H. Joachim Deeg

      Pages 365-393

Bone Marrow transplantation or Hematopoietic stem cell transplantation is a life saving procedure in a number of diseases,hematological and non hematological, which fail alternative medical management or have no other treatment options. It has transformed the lives of thousands of patients and their families around the world battling with fatal or debilitating diseases.There are many unique aspects of bone marrow transplantation which makes it very different from solid organ transplants.  There is an enormous amount of research going on in this field both at clinical and basic science levels.With the rapidly changing world and field of transplantation, there is a need for an authoritative and up to date resource for transplant professionals.
This book titled Contemporary Bone Marrow Transplantation aims to be a reference text comprehensively covering  various facets of hematopoietic stem cell transplants with latest insights about the technique and basic science

behind it . The book is the product of collective effort of transplant professionals round the world, and will reflect their experience as well as the current standard of care practices in Stem cell transplantation.The book will be divided into different sections focusing on the basic science of bone marrow transplant, the technical aspects of the procedure itself and the supportive care of transplant patients.There will also be a section each on epidemiology, upcoming trends and also case studies , which will discuss real case scenarios from the experience of the authors, to illustrate the practical challenges in managing bone marrow transplant recipients.

• Hematopoietic stem cells
• stem cell transplant
• Haploidentical stem cell transplantation
• Immunosuppressive therapy
• Cryopreservation in HSCT
• Transplant pharmacology
• surgical oncology

• Clinical Hematology Oncology and Hematopoietic Cell Transplantation, Tata Medical Center, Kolkata, India

  Mammen Chandy, Vivek S. Radhakrishnan

• Department of Pediatric Hematology-Oncology, Tata Medical Center, Kolkata, India

  Reghu K. Sukumaran

Prof. Mammen Chandy MD FRACP FRCPA FRCP DSc, an eminent physician and teacher for four decades, is the founder director of Tata Medical Center, Kolkata. He also leads the clinical hematology and hematopoietic cell transplantation Division at the center. After graduating from Christian Medical College (CMC) in Vellore, India, and completing his internal medicine training at the same institution, he underwent specialty training in hematology and hemato-pathology at Westmead Center, Sydney. Prof. Chandy was instrumental in setting up the hematology program at Christian Medical College, Vellore, and spent the major part of his career as its lead where he initiated the first specialty training program in hematology in the subcontinent. Prof. Chandy has been a pioneer in the field of bone marrow transplantation and is credited with establishing one of the first organized bone marrow transplant programs in the Indo-Pacific region. He has trained many generations of hematologists and transplant physicians. Prof. Chandy was also instrumental in initiating the bone marrow transplant program at the Sultan Quboos University in Muscat, Oman. Clinical and basic research in hematology have been his passion with over a hundred research publications in this field to his credit. He has been an advocate for developing inclusive clinical practices to manage economically challenged patients in resource constrained countries. The many awards and honors he has received are testimony to his immense contribution to hematology and bone marrow transplantation. The Royal College of Physicians (London) awarded him with the FRCP in 2010, and the CIBMTR in 2014 recognized his work by awarding him the “Distinguished Service” award. For his outstanding contribution to the field of medicine in the country, the Government of India honored Prof. Chandy with the Dr. BC Roy Award in 2012 and a coveted civilian honor, the Padmashree, in 2019.

Dr. Vivek S. Radhakrishnan MD DM MSc PDF, is a hemato-oncologist and bone marrow transplant physician by training. After completing his medical oncology residency at Madras Medical College, Chennai, Dr. Radhakrishnan underwent clinical postdoctoral specialization in hematological malignancies and bone marrow transplantation at TMC, and additional training in the bone marrow transplantation divisions at Duke University Medical Center, Durham, and MD Anderson Cancer Center, Houston. With nearly a decade’s experience in this field, he is the principal investigator in several investigator initiated clinical research studies in hematological malignancies and hematopoietic cellular therapies, and a recipient of prestigious research grants and society fellowships. His immediate past positions include the program director of the hematopoietic cell transplantation division and course-director of the accredited clinical residency programs, at TMC. He is the convener of the Immuno-Oncology working group in the institution, and a teacher in the Medical Oncology, Hematology and Hematopoietic Cell Transplantation training programs.


Dr. Reghu K. Sukumaran MD DCH DM PDF, is a senior consultant in the Department of Pediatric Hematology and Oncology at Tata Medical Center, Kolkata. He completed his pediatric oncology training at the Regional Cancer Center, Trivandrum. He underwent training in pediatric bone marrow transplantation at leading institutes in India and overseas. His areas of interest apart from bone marrow transplantation are immunooncology, bone sarcomas, and Hodgkin Lymphoma in children. He has more than a decade of experience as a pediatric attending physician and trainer in India.

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