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Stem Cells

Therapeutic Applications

  • Book
  • © 2019

Overview

Editors:
  1. Mariusz Z. Ratajczak

    1. Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, USA

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  • Detailed discussion on sources and types of a wide range of stem cells, as well as their therapeutic applications
  • Contributors are all recognized leaders in the field
  • Unique among the literature, this is a comprehensive and essential resource on regenerative medicine and stem cell therapies, bridging both the sources and types of stem cells and their clinical applications

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1201)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Potential Clinical Applications of Stem Cells in Regenerative Medicine

    • Suman Suman, Alison Domingues, Janina Ratajczak, Mariusz Z. Ratajczak
    Pages 1-22

  3. Genomic Instability of iPSCs and Challenges in Their Clinical Applications

    • Masahito Yoshihara, Akiko Oguchi, Yasuhiro Murakawa
    Pages 23-47

  4. Hematopoietic Stem and Progenitor Cells (HSPCs)

    • Kamila Bujko, Magda Kucia, Janina Ratajczak, Mariusz Z. Ratajczak
    Pages 49-77

  5. Neural Stem Cells

    • Julian P. Tuazon, Vanessa Castelli, Jea-Young Lee, Giovambattista B. Desideri, Liborio Stuppia, Anna Maria Cimini et al.
    Pages 79-91

  6. Therapeutic Potential of Mesenchymal Stem Cells in Immune-Mediated Diseases

    • Adam Eljarrah, Marina Gergues, Piotr W. Pobiarzyn, Oleta A. Sandiford, Pranela Rameshwar
    Pages 93-108

  7. Stem Cells in the Mammalian Gonads

    • Deepa Bhartiya, Sandhya Anand, Ankita Kaushik, Diksha Sharma
    Pages 109-123

  8. Stem and Progenitor Cells in the Pathogenesis and Treatment of Digestive Diseases

    • Wojciech Marlicz, Igor Łoniewski, Karolina Skonieczna-Żydecka
    Pages 125-157

  9. Stem Cells in Psychiatry

    • Jolanta Kucharska-Mazur, Mariusz Z. Ratajczak, Jerzy Samochowiec
    Pages 159-174

  10. The Role of Extracellular Vesicles as Paracrine Effectors in Stem Cell-Based Therapies

    • Stefania Bruno, Sharad Kholia, Maria Chiara Deregibus, Giovanni Camussi
    Pages 175-193

  11. Cellular Therapy for Ischemic Heart Disease: An Update

    • Hsuan Peng, Ahmed Abdel-Latif
    Pages 195-213

  12. Vasculogenic Stem and Progenitor Cells in Human: Future Cell Therapy Product or Liquid Biopsy for Vascular Disease

    • David M. Smadja
    Pages 215-237

  13. Epidermal Stem Cells

    • Anna M. Lenkiewicz
    Pages 239-259

  14. Stem Cells in Lungs

    • Andrzej Ciechanowicz
    Pages 261-274

  15. Targeting Purinergic Signaling and Cell Therapy in Cardiovascular and Neurodegenerative Diseases

    • Roberta Andrejew, Talita Glaser, Ágatha Oliveira-Giacomelli, Deidiane Ribeiro, Mariana Godoy, Alessandro Granato et al.
    Pages 275-353

  16. Plausible Links Between Metabolic Networks, Stem Cells, and Longevity

    • Magdalena Kucia, Mariusz Z. Ratajczak
    Pages 355-388

  17. Back Matter

    Pages 389-406
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Keywords

About this book

Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cellresearch field.    

Editors and Affiliations

  • Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, USA

    Mariusz Z. Ratajczak

About the editor

Mariusz Z. Ratajczak, M.D., Ph.D, D.Sci d.hc is since 2001 the Henry and Stella Hoenig Endowed Chair in Cancer Biology and the Director of the Developmental Biology Research Program at the University of Louisville JGBCC. Dr. Ratajczak earned his M.D. at the Pomeranian Medical University  (1981) and his Ph.D. and D.Sci at the Polish Academy of Sciences in Warsaw, Poland and completed fellowships at the University of Pennsylvania in Philadelphia, USA. He is an internationally known investigator in the field of adult stem cell biology, molecular mechanism that regulate stem cell trafficking and biological effect of extracellular microvesciles. Among Dr. Ratajczak’s prestigious awards are the 2014 Life achievement - Karl Landsteiner Award from the German Society of Transfusion Medicine and Immunohematotherapy, the 2008 Cancer Researcher of the Year award, the 2006 Award in Medicine and Biology from the Foundation for Polish Sciences, and the 2002 Chad Kopple Spirit Awardfrom the Leukemia and Lymphoma Society. Dr. Ratajczak was honored with the degree, doctoris honoris causa, from the Medical University of Silesia. He is a visiting Professor at Kansai University in Osaka, Japan, Fudan University in China and Honorary Professor at Xiamen University, China. He has published more than 500 peer-reviewed publications and is a frequent speaker at conferences worldwide. His work is supported by NIH grants.

Bibliographic Information

  • Book Title: Stem Cells

  • Book Subtitle: Therapeutic Applications

  • Editors: Mariusz Z. Ratajczak

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-030-31206-0

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-31205-3Published: 03 January 2020

  • Softcover ISBN: 978-3-030-31208-4Published: 26 August 2021

  • eBook ISBN: 978-3-030-31206-0Published: 02 January 2020

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIV, 406

  • Number of Illustrations: 2 b/w illustrations, 41 illustrations in colour

  • Topics: Stem Cells, Regenerative Medicine/Tissue Engineering, Cell Culture

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