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Advances in Biochemical Engineering/Biotechnology
cover

Catalytically Active Nucleic Acids

Herausgeber: Seitz, Harald, Stahl, Frank, Walter, Johanna-Gabriela (Eds.)

  • Highlights fundamental aspects of nucleic acids enzymes
  • Addresses methods and applications
  • Discusses challenges in and prospects for nucleic acid enzyme engineering
Weitere Vorteile

Dieses Buch kaufen

eBook 130,89 €
Preis für Deutschland (Brutto)
  • Die eBook-Version des Titels ist in Kürze verfügbar
  • Erscheinungstermin: 24. Oktober 2019
  • ISBN 978-3-030-29646-9
  • Versehen mit digitalem Wasserzeichen, DRM-frei
  • Erhältliche Formate:
  • eBooks sind auf allen Endgeräten nutzbar
Hardcover 235,39 €
Preis für Deutschland (Brutto)
  • Erscheinungstermin: 24. Oktober 2019
  • ISBN 978-3-030-29645-2
  • Kostenfreier Versand für Individualkunden weltweit
Über dieses Buch

This volume reviews numerous reaction mechanisms and applications of nucleic acids with catalytic activity. Written by an interdisciplinary team of authors, it provides an essential overview of these acids’ fundamental aspects, while also addressing associated methodologies such as nucleic acid enzyme engineering, peroxidase-mimicking DNAzymes and Aptazymes.

After the discovery of natural ribozymes – RNA molecules that mediate the cleavage and formation of phosphodiester bonds and the formation of peptide bonds – numerous artificial ribozymes with altered catalytic activities were produced by in vitro and in vivo selection. Unlike ribozymes, DNAzymes do not occur in nature. Although the catalytic activity of nucleic acid enzymes is usually much slower than that of proteins, nucleic acid enzymes with comparable catalytic activity have been obtained using stringent selection processes. The key advantages of these enzymes: they are e.g. smaller, easier to produce and purify than proteins, and can withstand denaturation, e.g. by heat.

Over the last few years, the number of publications on the applications of enzymatic nucleic acids has grown steadily. Summarizing the fundamentals and applications of these acids, this book will not only be an excellent resource for experts in the field but will also guide young researchers just starting out in this significant area.

Über den Autor

Harald Seitz has been a group leader at the Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses in Potsdam-Golm since 2012. He received his PhD (2000) and Diploma (1997) from the Free University Berlin and his postdoctoral degree (Habilitation (2012) from the University of Kassel. He worked for more than 10 years at Max-Planck Institute for Molecular Genetics in Berlin and moved in 2012 to the Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses. His work chiefly focuses on the (bio)analysis of different samples such as human serum or environmental samples using a variety of methods.

Dieses Buch kaufen

eBook 130,89 €
Preis für Deutschland (Brutto)
  • Die eBook-Version des Titels ist in Kürze verfügbar
  • Erscheinungstermin: 24. Oktober 2019
  • ISBN 978-3-030-29646-9
  • Versehen mit digitalem Wasserzeichen, DRM-frei
  • Erhältliche Formate:
  • eBooks sind auf allen Endgeräten nutzbar
Hardcover 235,39 €
Preis für Deutschland (Brutto)
  • Erscheinungstermin: 24. Oktober 2019
  • ISBN 978-3-030-29645-2
  • Kostenfreier Versand für Individualkunden weltweit
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Bibliografische Information

Bibliographic Information
Buchtitel
Catalytically Active Nucleic Acids
Herausgeber
  • Harald Seitz
  • Frank Stahl
  • Johanna-Gabriela Walter
Titel der Buchreihe
Advances in Biochemical Engineering/Biotechnology
Buchreihen Band
170
Copyright
2020
Verlag
Springer International Publishing
Copyright Inhaber
Springer Nature Switzerland AG
eBook ISBN
978-3-030-29646-9
DOI
10.1007/978-3-030-29646-9
Hardcover ISBN
978-3-030-29645-2
Buchreihen ISSN
0724-6145
Auflage
1
Seitenzahl
VII, 123
Anzahl der Bilder
26 schwarz-weiß Abbildungen, 12 Abbildungen in Farbe
Themen