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Pharmaceutical Biotechnology

Fundamentals and Applications

  • Textbook
  • © 2019

Overview

Editors:
  1. Daan J. A. Crommelin

    1. Utrecht University, Utrecht, The Netherlands

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  2. Robert D. Sindelar

    1. Faculty of Pharmaceutical Sciences and The Centre for Health Evaluation & Outcomes Sciences (CHEOS), The University of British Columbia (UBC), Vancouver, Canada

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    You can also search for this editor in PubMed   Google Scholar

  3. Bernd Meibohm

    1. College of Pharmacy, University of Tennessee, Health Science Center, Memphis, USA

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  • Every chapter thoroughly updated
  • Explains both basic science and applications of pharmaceutical biotechnology
  • Complete one-stop source for students and professionals
  • Written by experts in each subject
  • Includes pedagogical features like self assessment questions and answers
  • Loaded with over 250 color figures

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-xxiii
    Download chapter PDF

  2. Molecular Biotechnology: From DNA Sequence to Therapeutic Protein

    • Ronald S. Oosting
    Pages 1-18

  3. Biophysical and Biochemical Characteristics of Therapeutic Proteins

    • Wim Jiskoot, Daan J. A. Crommelin
    Pages 19-32

  4. Protein Stability and Characterization

    • Atanas Koulov
    Pages 33-56

  5. Production and Purification of Recombinant Proteins

    • Alfred Luitjens, Emile van Corven
    Pages 57-82

  6. Formulation of Biologics Including Biopharmaceutical Considerations

    • Daan J. A. Crommelin, Andrea Hawe, Wim Jiskoot
    Pages 83-103

  7. Pharmacokinetics and Pharmacodynamics of Therapeutic Peptides and Proteins

    • Bernd Meibohm
    Pages 105-137

  8. Immunogenicity of Therapeutic Proteins

    • Wim Jiskoot, Theo Rispens, Grzegorz Kijanka
    Pages 139-150

  9. Monoclonal Antibodies: From Structure to Therapeutic Application

    • Rong Deng, C. Andrew Boswell, Wendy S. Putnam, Meina T. Tang, Amit Garg, Chunze Li et al.
    Pages 151-190

  10. Genomics, Other “OMIC” Technologies, Precision Medicine, and Additional Biotechnology-Related Techniques

    • Robert D. Sindelar
    Pages 191-237

  11. Dispensing Biotechnology Products: Handling, Professional Education, and Product Information

    • Robert D. Sindelar
    Pages 239-251

  12. Economic Considerations in Medical Biotechnology

    • Amit S. Patel, Kartick P. Shirur
    Pages 253-263

  13. Regulatory Framework for Biosimilars

    • Vinod P. Shah, Daan J. A. Crommelin
    Pages 265-274

  14. An Evidence-Based Practice Approach to Evaluating Biotechnologically Derived Medications

    • James P. McCormack
    Pages 275-280

  15. Vaccines

    • Wim Jiskoot, Gideon F. A. Kersten, Enrico Mastrobattista, Bram Slütter
    Pages 281-304

  16. Oligonucleotides

    • Raymond M. Schiffelers, Erik Oude Blenke, Enrico Mastrobattista
    Pages 305-322

  17. Gene Therapy

    • Hao Wu, Amit Kumar Chaudhary, Ram I. Mahato
    Pages 323-355

  18. Advanced Therapies: Clinical, Non-clinical and Quality Considerations

    • Karin H. Hoogendoorn
    Pages 357-402

  19. Insulin

    • John M. Beals, Michael R. DeFelippis, Chad D. Paavola, David P. Allen, Ashish Garg, D. Bruce Baldwin
    Pages 403-427

  20. Follicle-Stimulating Hormone

    • Tom Sam, Renato de Leeuw
    Pages 429-435
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Keywords

About this book

This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry. The Fifth Edition completely updates the previous edition, and also includes additional coverage on the newer approaches such as oligonucleotides, siRNA, gene therapy and nanotech and enzyme replacement therapy.





Editors and Affiliations

  • Utrecht University, Utrecht, The Netherlands

    Daan J. A. Crommelin

  • Faculty of Pharmaceutical Sciences and The Centre for Health Evaluation & Outcomes Sciences (CHEOS), The University of British Columbia (UBC), Vancouver, Canada

    Robert D. Sindelar

  • College of Pharmacy, University of Tennessee, Health Science Center, Memphis, USA

    Bernd Meibohm

About the editors

Daan J.A. Crommelin is Professor Emeritus Department of Pharmaceutical Sciences, Utrecht Institute for Pharmaceutical Sciences at Utrecht University, Utrecht, The Netherlands and Adjunct Professor in the Department of Pharmaceutics and Pharmaceutical Chemistry at the University of Utah, Salt Lake City, UT, USA


Robert D. Sindelar is Professor and former Dean Faculty of Pharmaceutical Sciences and The Centre for Health Evaluation & Outcomes Sciences (CHEOS), The University of British Columbia (UBC), Vancouver, BC, Canada and President of the Global Drug Commercialization Centre (GDCC)-China and Vice-President GDCC-worldwide, Chengdu, China


Bernd Meibohm is Professor of Pharmaceutical Sciences and Associate Dean for Research and Graduate Programs at the University of Tennessee Health Science Center, College of Pharmacy, Memphis, TN, USA


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