CYBER DEAL: 50% Rabatt auf Springer eBooks | Angebot sichern!

Methods in Molecular Biology

Tau Protein

Methods and Protocols

Herausgeber: Smet-Nocca, Caroline (Ed.)

Vorschau
  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
Weitere Vorteile

Dieses Buch kaufen

eBook 96,29 €
Preis für Deutschland (Brutto)
  • ISBN 978-1-4939-6598-4
  • Versehen mit digitalem Wasserzeichen, DRM-frei
  • Erhältliche Formate: EPUB, PDF
  • eBooks sind auf allen Endgeräten nutzbar
  • Sofortiger eBook Download nach Kauf
Hardcover 149,79 €
Preis für Deutschland (Brutto)
Softcover 133,74 €
Preis für Deutschland (Brutto)
Über dieses Buch

This detailed volume gathers basic and advanced methods and protocols from in vitro assays and in vivo models to address the molecular and functional aspects of tau physiopathology. Divided into five parts that illustrate the underlying molecular mechanisms of Tau functions and dysfunctions in Alzheimer’s disease and other dementia referred to as tauopathies, this volume discusses timely topics such as: conformational studies of native tau protein and investigation of its physiological function in microtubules binding and tubulin polymerization; in vitro methods of formation and detection of tau oligomers and PHF-like fibrils; characterization and in vitro introduction of post-translational modifications on tau proteins for further functional studies; analytical tools for the detection of tau proteins, their modifications and cellular interactions, and MAPT gene mutations in various biological samples; and cellular and in vivo models for the investigations of tau physiopathology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Practical and cutting-edge, Tau Protein: Methods and Protocols is a valuable resource that addresses the most recent aspects of Alzheimer’s disease research related to Tau protein and state-of-the-art experimental techniques. It targets a broad scientific audience including molecular biologists and biochemists, as well as all researchers interested in exploring the functions of tau proteins.

Inhaltsverzeichnis (28 Kapitel)

Inhaltsverzeichnis (28 Kapitel)
  • Conformational Dynamics of Intracellular Tau Protein Revealed by CD and SAXS

    Seiten 3-20

    Gorantla, Nalini Vijay (et al.)

  • Global Conformation of Tau Protein Mapped by Raman Spectroscopy

    Seiten 21-31

    Gorantla, Nalini Vijay (et al.)

  • Molecular Dynamics Simulation of Tau Peptides for the Investigation of Conformational Changes Induced by Specific Phosphorylation Patterns

    Seiten 33-59

    Gandhi, Neha S. (et al.)

  • Tau Interaction with Tubulin and Microtubules: From Purified Proteins to Cells

    Seiten 61-85

    Bessa, Tiphany (et al.)

  • X-Ray Structural Study of Amyloid-Like Fibrils of Tau Peptides Bound to Small-Molecule Ligands

    Seiten 89-100

    Tayeb-Fligelman, Einav (et al.)

Dieses Buch kaufen

eBook 96,29 €
Preis für Deutschland (Brutto)
  • ISBN 978-1-4939-6598-4
  • Versehen mit digitalem Wasserzeichen, DRM-frei
  • Erhältliche Formate: EPUB, PDF
  • eBooks sind auf allen Endgeräten nutzbar
  • Sofortiger eBook Download nach Kauf
Hardcover 149,79 €
Preis für Deutschland (Brutto)
Softcover 133,74 €
Preis für Deutschland (Brutto)
Loading...

Wir empfehlen

Loading...

Bibliografische Information

Bibliographic Information
Buchtitel
Tau Protein
Buchuntertitel
Methods and Protocols
Herausgeber
  • Caroline Smet-Nocca
Titel der Buchreihe
Methods in Molecular Biology
Buchreihen Band
1523
Copyright
2017
Verlag
Humana Press
Copyright Inhaber
Springer Science+Business Media New York
eBook ISBN
978-1-4939-6598-4
DOI
10.1007/978-1-4939-6598-4
Hardcover ISBN
978-1-4939-6596-0
Softcover ISBN
978-1-4939-8246-2
Buchreihen ISSN
1064-3745
Auflage
1
Seitenzahl
XVIII, 432
Anzahl der Bilder
19 schwarz-weiß Abbildungen, 64 Abbildungen in Farbe
Themen