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Mass Spectrometry Imaging of Small Molecules

Methods and Protocols

  • Book
  • © 2022

Overview

Editors:
  1. Young-Jin Lee

    1. Department of Chemistry, Iowa State University, Ames, USA

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2437)

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Table of contents (18 protocols)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Innovations in Instrumental Methods for Mass Spectrometry Imaging

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Gas-Phase Ion–Ion Reactions for Lipid Identification in Biological Tissue Sections

      • Boone M. Prentice
      Pages 3-19

    3. MALDI-2 and t-MALDI-2 Mass Spectrometry Imaging

      • Klaus Dreisewerd, Tanja Bien, Jens Soltwisch
      Pages 21-40

    4. Ambient Mass Spectrometry Imaging of Small Molecules from Cells and Tissues

      • Jae Young Kim, Heejin Lim, Dae Won Moon
      Pages 41-59

    5. Single-Cell Metabolomics with Rapid Determination of Chemical Formulas from Isotopic Fine Structures

      • Laith Z. Samarah, Akos Vertes, Christopher R. Anderton
      Pages 61-75

    6. TOF-SIMS Imaging of Biological Tissue Sections and Structural Determination Using Tandem MS

      • Sebastiaan Van Nuffel, Alain Brunelle
      Pages 77-86

  5. New Types of Applications

    1. Front Matter

      Pages 195-195
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    2. Enhancing Metabolite Coverage for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Through Multiple On-Tissue Chemical Derivatizations

      • Kelly C. O’Neill, Maria Emilia Dueñas, Evan Larson, Trevor T. Forsman, Young-Jin Lee
      Pages 197-213

    3. Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Glycogen In Situ

      • Tara R. Hawkinson, Ramon C. Sun
      Pages 215-228
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Keywords

About this book

This volume presents updated methods and new developments in the field of mass spectrometry imaging. Chapters guide readers through four parts covering imaging, software,  data analysis, new instrumentation, and new methodological approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 Authoritative and cutting-edge, Mass Spectrometry Imaging of Small Molecules aims to be a useful practical guide to researchers to help further their study in this field. 

Editors and Affiliations

  • Department of Chemistry, Iowa State University, Ames, USA

    Young-Jin Lee

Bibliographic Information

  • Book Title: Mass Spectrometry Imaging of Small Molecules

  • Book Subtitle: Methods and Protocols

  • Editors: Young-Jin Lee

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-2030-4

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2022

  • Hardcover ISBN: 978-1-0716-2029-8Published: 14 December 2021

  • Softcover ISBN: 978-1-0716-2032-8Published: 15 December 2022

  • eBook ISBN: 978-1-0716-2030-4Published: 13 December 2021

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: X, 275

  • Number of Illustrations: 9 b/w illustrations, 65 illustrations in colour

  • Topics: Mass Spectrometry, Biochemistry, general

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