Editors:
Includes cutting-edge methods and protocols
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts
Part of the book series: Methods in Molecular Biology (MIMB, volume 2253)
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Table of contents (15 protocols)
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Front Matter
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Back Matter
About this book
This volume explores the basic issues of “allostery” and “network” that are fundamental to studying this field. Chapters in this book look at how the basic “machine-like” proteins, that are similar to “human machines,” need to be organized, architecturally, to relate to different organizational layers. Chapters cover topics such as methodological/computational factors focused on links between allostery and network formalism; the presence of oscillating modes transversing the structure and underlying network wiring of the allosteric process; the “action at distance” by transduction of signals across an organized network structure; and the P53 protein located at the cross-road of cell cycle regulation, genome integrity, and cancer development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Thorough and practical, Allostery: Methods and Protocols is a valuable resource for any scientists and researcher interested in learning more about this developing field.
Editors and Affiliations
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Unit of Chemical-Physics Fundamentals in Chemical Engineering Department of Engineering, Universitá Campus Bio-Medico di Rome, Rome, Italy
Luisa Di Paola
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Environment and Health Department, Instituto Superiore di Sanità, Rome, Italy
Alessandro Giuliani
Bibliographic Information
Book Title: Allostery
Book Subtitle: Methods and Protocols
Editors: Luisa Di Paola, Alessandro Giuliani
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-0716-1154-8
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021
Hardcover ISBN: 978-1-0716-1153-1Published: 15 December 2020
Softcover ISBN: 978-1-0716-1156-2Published: 16 December 2021
eBook ISBN: 978-1-0716-1154-8Published: 14 December 2020
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XII, 274
Number of Illustrations: 8 b/w illustrations, 91 illustrations in colour
Topics: Protein Science