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Methods in Molecular Biology

DNA Modifications

Methods and Protocols

Herausgeber: Ruzov, Alexey, Gering, Martin (Eds.)

Vorschau
  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts
Weitere Vorteile

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  • ISBN 978-1-0716-0876-0
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Hardcover 235,39 €
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Über dieses Buch

This book provides an overview of methods and experimental protocols that are currently used to analyze the presence and abundance of non-canonical DNA nucleotides in different biological systems. Focusing particularly on the newly discovered and less studied DNA modifications that are enzymatically produced and are likely to play specific roles in various biological processes, the volume explores chromatography- and mass spectrometry-based techniques for the detection and quantification of DNA modifications, antibody-based approaches to study their spatial distribution in different cells and tissues, and methods to analyze their genomic distribution with the help of bioinformatics tools that interrogate the corresponding datasets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 
Authoritative and comprehensive, DNA Modifications: Methods and Protocols serves as an ideal guide to research scientists and PhD students in this rapidly developing discipline, and, thus, will ultimately contribute to deciphering the roles of non-canonical DNA nucleotides in different biological systems.

Inhaltsverzeichnis (34 Kapitel)

Inhaltsverzeichnis (34 Kapitel)
  • Modified Forms of Cytosine in Eukaryotes: DNA (De)methylation and Beyond

    Seiten 3-13

    Eleftheriou, Maria (et al.)

  • Evidence for Noncytosine Epigenetic DNA Modifications in Multicellular Eukaryotes: An Overview

    Seiten 15-25

    Lowe, Paige (et al.)

  • Mass Spectrometry-Based Analysis of DNA Modifications: Potential Applications in Basic Research and Clinic

    Seiten 27-35

    Olinski, Ryszard (et al.)

  • Mapping DNA Methylation in Mammals: The State of the Art

    Seiten 37-50

    Lentini, Antonio (et al.)

  • Detection of Modified Bases in Bacteriophage Genomic DNA

    Seiten 53-66

    Lee, Yan-Jiun (et al.)

Dieses Buch kaufen

eBook  
  • ISBN 978-1-0716-0876-0
  • Versehen mit digitalem Wasserzeichen, DRM-frei
  • Erhältliche Formate: PDF, EPUB
  • eBooks sind auf allen Endgeräten nutzbar
Hardcover 235,39 €
Preis für Deutschland (Brutto)
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Bibliografische Information

Bibliographic Information
Buchtitel
DNA Modifications
Buchuntertitel
Methods and Protocols
Herausgeber
  • Alexey Ruzov
  • Martin Gering
Titel der Buchreihe
Methods in Molecular Biology
Buchreihen Band
2198
Copyright
2021
Verlag
Springer US
Copyright Inhaber
The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-0716-0876-0
DOI
10.1007/978-1-0716-0876-0
Hardcover ISBN
978-1-0716-0875-3
Buchreihen ISSN
1064-3745
Auflage
1
Seitenzahl
XVI, 495
Anzahl der Bilder
27 schwarz-weiß Abbildungen, 70 Abbildungen in Farbe
Themen