Progress in Cell Cycle Research

1. Front Matter

   Pages i-viii

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2. A quest for cytoplasmic factors that control the cell cycle

   • Yoshio Masui

   Pages 1-13

3. G1/S regulatory mechanisms from yeast to man

   • Steven I. Reed

   Pages 15-27

4. Regulation of G1 progression in fission yeast by the rum1 ⁺ gene product

   • Cristina Martín-Castellanos, Sergio Moreno

   Pages 29-35

5. Progression through G1 and S phases of adult rat hepatocytes

   • Pascal Loyer, Guenadi Ilyin, Sandrine Cariou, Denise Glaise, Anne Corlu, Christiane Guguen-Guillouzo

   Pages 37-47

6. A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry

   • Josée N. Lavoie, Nathalie Rivard, Gilles L’Allemain, Jacques Pouysségur

   Pages 49-58

7. The plant cell cycle: conserved and unique features in mitotic control

   • Peter C. L. John

   Pages 59-72

8. The functions of Myc in cell cycle progression and apoptosis

   • Philipp Steiner, Bettina Rudolph, Daniel Müller, Martin Eilers

   Pages 73-82

9. DNA replication licensing factor

   • James P. J. Chong, J. Julian Blow

   Pages 83-90

10. Tyrosine kinases wee1 and mik1 as effectors of DNA replication checkpoint control

    • Jérôme Tourret, Frank McKeon

    Pages 91-97

11. Regulation of Cdc2 activity by phosphorylation at T14/Y15

    • Lynne D. Berry, Kathleen L. Gould

    Pages 99-105

12. The family of polo-like kinases

    • Lynne D. Berry, Roy M. Golsteyn, Heidi A. Lane, Kirsten E. Mundt, Lionel Arnaud, Erich A. Nigg

    Pages 107-114

13. Ubiquitin-dependent proteolysis and cell cycle control in yeast

    • Kristin T. Chun, Neal Mathias, Mark G. Goebl

    Pages 115-127

14. Suc1: cdc2 affinity reagent or essential cdk adaptor protein?

    • Lee Vogel, Blandine Baratte

    Pages 129-135

15. Structural basis for chemical inhibition of CDK2

    • Sung-Hou Kim, Ursula Schulze-Gahmen, Jeroen Brandsen, Walter Filgueira de Azevedo Jr.

    Pages 137-145

16. Apoptosis and the cell cycle

    • Rati Fotedar, Ludger Diederich, Arun Fotedar

    Pages 147-163

17. DNA damage checkpoints: Implications for cancer therapy

    • Patrick M. O’Connor, Saijun Fan

    Pages 165-173

18. Cellular responses to antimetabolite anticancer agents: cytostasis versus cytotoxicity

    • Janet A. Houghton, Peter J. Houghton

    Pages 175-185

19. Telomeres, telomerase, and the cell cycle

    • Karen J. Buchkovich

    Pages 187-195

20. The cyclin C/Cdk8 kinase

    • Vincent Leclerc, Pierre Léopold

    Pages 197-204

Now in its second year, Progress in Cell Cycle Research was conceived to serve as an up to date introduction to various aspects of the cell division cycle. Although an annual review in any field of scientific investigation can never be as current as desired, especially in the cell cycle field, we hope that this volume will be helpful to students, to recent graduates considering a de1liation in subject and to investigators at the fringe of the cell cycle field wishing to bridge frontiers. An instructive approach to many subjects in biology is often to make comparisons between evolutionary distant organisms. If one is willing to accept that yeast represent a model primitive eukaryote, then it is possible to make some interesting comparisons of cell cycle control mechanisms between mammals and our little unicellular cousins. By and large unicellular organisms have no need for intracellular communication. With the exception of the mating phenomenon in S. cerevisiae and perhaps some nutritional sensing mechanisms, cellular division of yeast proceeds with complete disregard for neighbourly communication. Multicellular organisms on the other hand, depend entirely on intracellular communication to maintain structural integrity. Consequently, elaborate networks have evolved to either prevent or promote appropriate cell division in multicellular organisms. Yet, as described in chapter two the rudimentary mechanisms for fine tuning the cell division cycle in higher eukaryotes are already apparent in yeast.

• DNA
• apoptosis
• cell division
• cyclin
• regulation

• Centre National de la Recherche Scientifique, Roscoff, France

  Laurent Meijer, Silvana Guidet, Lee Vogel

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