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Regional science offers a multi-disciplinary approach for understanding complex spatial phenomena, combining regional economics, social and economic geography, urban economics, transportation science, environmental science, political science, and planning theory. It provides a powerful scientific toolbox that is nowadays being used in many spatial analyses. Its history dates back to the 1950s, and is now a mature science with thousands of representatives all over the world. Over the past decades, regional science has shown both a broadening and deepening of its scope characterized by novel methodological, theoretical and applied research orientations.