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Integrated Analytical Systems

Microfluidics for Single-Cell Analysis

Editors: Lin, Jin-Ming (Ed.)

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  • Summarizes the various microfluidic-based single cell analysis methods
  • Reviews the state-of-the-art techniques showcasing the pros and cons of each method in details
  • Offers lessons learned and tips from front-line investigators to help researchers overcome bottlenecks in reality
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  • ISBN 978-981-329-729-6
  • Digitally watermarked, DRM-free
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  • ISBN 978-981-329-728-9
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About this book

This book summarizes the various microfluidic-based approaches for single-cell capture, isolation, manipulation, culture and observation, lysis, and analysis. Single-cell analysis reveals the heterogeneities in morphology, functions, composition, and genetic performance of seemingly identical cells, and advances in single-cell analysis can overcome the difficulties arising due to cell heterogeneity in the diagnostics for a targeted model of disease. This book provides a detailed review of the state-of-the-art techniques presenting the pros and cons of each of these methods. It also offers lessons learned and tips from front-line investigators to help researchers overcome bottlenecks in their own studies. Highlighting a number of techniques, such as microfluidic droplet techniques, combined microfluidics-mass-spectrometry systems, and nanochannel sampling, it describes in detail a new microfluidic chip-based live single-cell extractor (LSCE) developed in the editor’s laboratory, which opens up new avenues to use open microfluidics in single-cell extraction, single-cell mass spectrometric analysis, single-cell adhesion analysis and subcellular operations. Serving as both an elementary introduction and advanced guidebook, this book interests and inspires scholars and students who are currently studying or wish to study microfluidics-based cell analysis methods.

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Table of contents (9 chapters)

Table of contents (9 chapters)
  • Advances of Single-Cell Analysis on Microfluidics

    Pages 1-26

    Huang, Qiushi (et al.)

  • Microfluidic Technology for Single-Cell Capture and Isolation

    Pages 27-51

    Wu, Jing (et al.)

  • Single-Cell Culture and Analysis on Microfluidics

    Pages 53-84

    Li, Weiwei (et al.)

  • Microfluidic Technology for Single-Cell Manipulation

    Pages 85-117

    Zhang, Weifei (et al.)

  • Droplet-Based Microfluidics for Single-Cell Encapsulation and Analysis

    Pages 119-141

    Chen, Qiushui (et al.)

Buy this book

eBook n/a
  • ISBN 978-981-329-729-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-981-329-728-9
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Microfluidics for Single-Cell Analysis
Editors
  • Jin-Ming Lin
Series Title
Integrated Analytical Systems
Copyright
2019
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-329-729-6
DOI
10.1007/978-981-32-9729-6
Hardcover ISBN
978-981-329-728-9
Series ISSN
2196-4475
Edition Number
1
Number of Pages
VII, 261
Number of Illustrations
7 b/w illustrations, 99 illustrations in colour
Topics