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Hereditary Breast and Ovarian Cancer

Molecular Mechanism and Clinical Practice

  • Book
  • © 2021

Overview

Editors:
  1. Seigo Nakamura

    1. Department of Breast Surgical Oncology, Showa University, School of Medicine, Tokyo, Japan

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    You can also search for this editor in PubMed   Google Scholar

  2. Daisuke Aoki

    1. Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan

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    You can also search for this editor in PubMed   Google Scholar

  3. Yoshio Miki

    1. Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

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    You can also search for this editor in PubMed   Google Scholar

  • Discusses the molecular mechanisms, genetic testing and counseling, and variants of unknown significance

  • Includes a special chapter on the recent findings from the HBOC database, ethical issues and the parp inhibitors

  • Appeals to breast surgeons, medical oncologists, gynecological oncologists and genetic counselors

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. History, Advancements, and Future Strategies

    • Reiko Yoshida
    Pages 1-14

  3. Molecular Basis of BRCA1 and BRCA2: Homologous Recombination Deficiency and Tissue-Specific Carcinogenesis

    • Tomohiko Ohta, Wenwen Wu
    Pages 15-29

  4. Genetic Testing

    • Sana Yokoi
    Pages 31-46

  5. Variants of Uncertain Significances in Hereditary Breast and Ovarian Cancer

    • Yuki Yoshino, Natsuko Chiba
    Pages 47-64

  6. Genetic Counseling in Hereditary Breast and Ovarian Cancer

    • Mayuko Inuzuka
    Pages 65-77

  7. Hereditary Breast Cancer

    • Minoru Miyashita, Takanori Ishida
    Pages 79-92

  8. Hereditary Ovarian Cancer

    • Kenta Masuda, Megumi Satake, Daisuke Aoki
    Pages 93-106

  9. Risk-Based Breast Cancer Screening

    • Wakana Murakami, Mitsuhiro Tozaki, Kelly E. McCann, Stephanie Lee-Felker
    Pages 107-128

  10. Chemoprevention for Breast Cancer

    • Rurina Watanuki, Aiko Nagayama, Tetsu Hayashida, Yuko Kitagawa
    Pages 129-148

  11. Chemoprevention for Ovarian Cancer

    • Hiroshi Kobayashi
    Pages 149-167

  12. Risk-Reducing Mastectomy (RRM)

    • Rina Kotake, Yasue Tsuchida, Kumiko Kida, Hideko Yamauchi
    Pages 169-182

  13. Risk-Reducing Salpingo-oophorectomy (RRSO)

    • Yusuke Kobayashi, Daisuke Aoki
    Pages 183-191

  14. Panel Testing

    • Yasuyuki Kojima
    Pages 193-210

  15. Germline Findings Through Precision Oncology for Ovarian Cancer

    • Mika Okazawa-Sakai, Akira Hirasawa
    Pages 211-226

  16. Germline Findings from Genetic Testing for Breast Cancer

    • Akihiro Sakurai
    Pages 227-241

  17. Hereditary Breast and Ovarian Cancer (HBOC) Database in Japan

    • Masami Arai, The Registration Committee of the Japanese Organization of Hereditary Breast and Ovarian Cancer (JOHBOC)
    Pages 243-257

  18. Ethical Issues: Overview in Genomic Analysis and Clinical Context

    • Izen Ri, Kaori Muto
    Pages 259-279

  19. PARP Inhibitors: Mechanism of Action

    • Shigeaki Sunada, Yoshio Miki
    Pages 281-292

  20. PARPi: Efficacy in Hereditary Breast Cancer

    • Akiyo Yoshimura
    Pages 293-312
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Keywords

About this book

This highly informative and clearly written book presents the basic science and the latest data on hereditary breast and ovarian cancer (HBOC) to provide an up-to-date and holistic overview of the disease. It starts off by presenting the molecular mechanisms, genetic testing and counseling, and variants of unknown significance (VUS) to help readers understand the contemporary interpretation of the disease. Further chapters focus on the surveillance, diagnosis and treatment, including chemoprevention, risk reduction and drug development based on molecular mechanisms. It also includes a chapter on the latest findings from the HBOC database, ethical issues and the parp inhibitors, and discusses innovative thinking to manage and understand the disease.

Hereditary Breast and Ovarian Cancer - Molecular Mechanism and Clinical Practice offers breast surgeons, medical oncologists, gynecological oncologists and genetic counselors a comprehensive overview of the disease. Providing insights into recent scientific findings and further avenues for investigation, it is also a thought-provoking and informative read for researchers and scholars.








Editors and Affiliations

  • Department of Breast Surgical Oncology, Showa University, School of Medicine, Tokyo, Japan

    Seigo Nakamura

  • Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan

    Daisuke Aoki

  • Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

    Yoshio Miki

About the editors

Seigo Nakamura

Department of Breast Surgical Oncology

Showa University, School of Medicine

Tokyo, Japan


 

Daisuke Aoki

Department of Obstetrics and Gynecology,

Keio University School of Medicine,

Tokyo, Japan


 

Yoshio Miki

Department of Molecular Genetics, Medical Research Institute,

Tokyo Medical and Dental University,

Tokyo, Japan


Bibliographic Information

  • Book Title: Hereditary Breast and Ovarian Cancer

  • Book Subtitle: Molecular Mechanism and Clinical Practice

  • Editors: Seigo Nakamura, Daisuke Aoki, Yoshio Miki

  • DOI: https://doi.org/10.1007/978-981-16-4521-1

  • Publisher: Springer Singapore

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2021

  • Hardcover ISBN: 978-981-16-4520-4Published: 21 October 2021

  • Softcover ISBN: 978-981-16-4523-5Published: 22 October 2022

  • eBook ISBN: 978-981-16-4521-1Published: 20 October 2021

  • Edition Number: 1

  • Number of Pages: VIII, 324

  • Number of Illustrations: 7 b/w illustrations, 24 illustrations in colour

  • Topics: Oncology, Surgical Oncology, Cancer Research, Human Genetics, Molecular Medicine

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