Overview
- Reviews the latest literature in vascular systems from a view of biomedical engineers
- Covers the state-of-the-art research in endothelial surface glycocalyx, in nuclear envelope proteins, and in smooth muscle cell and surrounding extracellular matrix in maintaining vascular functions, in vulnerable plaque and abdominal aortic aneurysm, in transport across the blood-brain barrier, and in vascular system in response to temperature changes
- Presents mathematical models for blood cell movement and interactions between circulating cells and endothelial cells forming the microvessel wall
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1097)
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Table of contents (17 chapters)
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Front Matter
Keywords
- microvascular transport
- blood-brain barrier
- interactions circulation endothelial cells
- endothelial surface glycocalyx barrier
- endothelial barrier water transport
- endothelial surface glycocalyx mechanosensor
- mechanosensing mechanoregulation extracellular matrix
- atherosclerotic plaque microcalcifications
- models thermal regulation cell
- abdominal aortic aneurysms
About this book
This book introduces the latest research in molecular, cellular, and tissue engineering of the vascular system. Topics covered include the roles of endothelial surface glycocalyx as a mechano-sensor and transducer for blood flow, a barrier to water and solute transport across the vascular wall and to the interaction between circulating cells and the vessel wall, the roles of nuclear envelope proteins and nuclear lamina in regulating vascular functions under blood flow-induced forces, and the roles of smooth muscle cells and extracellular components in arterial vasoconstriction. Other topics covered include non-surgical vascular interventions for coronary artery diseases, genesis and mechanisms of atherosclerotic plaque microcalcifications and human abdominal aortic aneurysms, experiments and modelling for red blood cell and tumor cell movement in microcirculation, transport across the blood-brain barrier and its role in Alzheimer’s disease, mathematical models for cell survival after hyperthermia, application of hypothermia in enhancing treatment for brain and spinal cord injuries, and damage of eardrums due to blast waves. This is an ideal book for biomedical engineers and researchers, medical researchers, and students in biomedical engineering and medical sciences.
Editors and Affiliations
About the editors
Bingmei M Fu is a Professor of Biomedical Engineering at The City College of the City University of New York. She received her BS and MS in Modern Mechanics from the University of Science and Technology of China, her Ph.D. in Mechanical Engineering from the City University of New York and her postdoctoral training in School of Medicine at the University of California, Davis. Prior to her appointment at City College, she was an Associate Professor in Mechanical Engineering at the University of Nevada, Las Vegas. She is a fellow of the American Institute for Medical and Biological Engineering and a member of the Biomedical Engineering Society and the American Association for the Advancement of Science. Her major research activities involve modelling nano and micro transport phenomena in the microcirculation, and corresponding in vivo animal and in vitro culture cell experiments.
Neil T. Wright is an Associate Professor of Mechanical Engineering at Michigan State University. He received his BS in Engineering Science and Mechanics from Virginia Tech, his MS in Mechanical Engineering from the University of Colorado, and his PhD in Mechanical Engineering and Applied Mechanics from the University of Pennsylvania. Prior to his appointment at Michigan State, he was an Associate Professor at the University of Maryland, Baltimore County. He is a fellow of the American Society of Mechanical Engineers and a member of the Biomedical Engineering Society and the American Association for the Advancement of Science. His laboratory measures the thermophysical properties of biological materials and superconducting niobium.
Bibliographic Information
Book Title: Molecular, Cellular, and Tissue Engineering of the Vascular System
Editors: Bingmei M. Fu, Neil T. Wright
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-319-96445-4
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG, part of Springer Nature 2018
Hardcover ISBN: 978-3-319-96444-7Published: 26 October 2018
Softcover ISBN: 978-3-030-07193-6Published: 28 December 2018
eBook ISBN: 978-3-319-96445-4Published: 12 October 2018
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VIII, 334
Number of Illustrations: 19 b/w illustrations, 65 illustrations in colour
Topics: Regenerative Medicine/Tissue Engineering, Biomedical Engineering/Biotechnology, Cardiology, Biomedical Engineering and Bioengineering