Overview
- A comprehensive overview of strategies for the generation of protein inhibitors
- Covering prediction, selection and the biological application of protein inhibitors
- Extensive discussion of future approaches and applications of protein inhibitors
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 917)
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Table of contents (12 chapters)
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Front Matter
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Methods of Structure Prediction
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Front Matter
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Antibodies
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Front Matter
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Peptides, Small Molecules and Aptamers
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Front Matter
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Angiogenesis Inhibitors
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Front Matter
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Back Matter
Keywords
About this book
This book presents an overview of the most relevant protein knockdown techniques. Readers will find a description of the generation and use of recombinant human antibodies, ER intrabodies and peptides as well as a description of the working mechanism and potential of the inhibitory action of each of these molecules. The book will also describe the selection and activity of a number of phosphatases, aptamers and allosteric modulators, focusing on A G protein coupled receptors. The book starts with a chapter on the in silico prediction of target-inhibitor interactions.
Key aspects of this book are:
- Selection strategies for monoclonal and recombinant human antibodies
- Selection strategies for ER intrabodies, peptides and aptamers
- Examples of the most efficient inhibitors and their applications in protein biochemistry and cell biology- Antibodies for cancer therapy and inhibitors of angiogenesis.
The book will be of great interest to scientists and students working in the life sciences on all areas related to protein biology. The variety of methods to modulate the activities of specific proteins which are introduced here will be of great benefit to the reader who is interested in general protein research or to readers who have very specific protein related questions.
Editors and Affiliations
Bibliographic Information
Book Title: Protein Targeting Compounds
Book Subtitle: Prediction, Selection and Activity of Specific Inhibitors
Editors: Thomas Böldicke
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-319-32805-8
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016
Hardcover ISBN: 978-3-319-32804-1Published: 06 June 2016
Softcover ISBN: 978-3-319-81373-8Published: 30 May 2018
eBook ISBN: 978-3-319-32805-8Published: 28 May 2016
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VIII, 288
Number of Illustrations: 18 b/w illustrations, 31 illustrations in colour
Topics: Immunology