Resistance to Targeted Anti-Cancer Therapeutics

Resistance of Cancer Cells to CTL-Mediated Immunotherapy

Editors: Bonavida, Benjamin, Chouaib, Salem (Eds.)

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  • Explores the inhibition of CTL-cytotoxic function by tumor-derived T-regulatory cells, along with the inhibition of cytotoxic function by tumor induction of hypoxia
  • Discusses the overexpression of transcription factors that regulate resistance
  • Appeals to cancer researchers, biologists and immunologists
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eBook 118,99 €
price for China (P.R.) (gross)
  • ISBN 978-3-319-17807-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 149,99 €
price for China (P.R.) (gross)
  • ISBN 978-3-319-17806-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover 140,17 €
price for China (P.R.) (gross)
  • ISBN 978-3-319-38067-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.

About the authors

Benjamin Bonavida, Ph.D., is Professor, UCLA David Geffen School of Medicine for the Department of Microbiology, Immunology & Molecular Genetics. He is also Member, Department of Defense Congressionally Directed Medical Research Program, Member, National Cancer Institute SPORE Program, Member, International Scientific Advisory Board of the Israel Cancer Research Foundation, among other accomplishments. He is currently a scientific reviewer for several journals and a member of editorial boards including Journal of Clinical Immunology, International Journal of Oncology, and Cancer Biotherapy & Radiopharmaceuticals. He has published over 450 papers and reviews, has received more than 7,980 citations, and has edited four Springer volumes.

Salem Chouaib, Ph.D., is Head, Cancer Immunology Division at Institut Gustave Roussy. His research focuses on augmenting cytotoxic T cell immunity and studies how tumors evade the immune system. Dr. Chouaib has published more than 239 scientific papers and reviews, and has received more than 5,490 citations.

Table of contents (15 chapters)

Table of contents (15 chapters)

Buy this book

eBook 118,99 €
price for China (P.R.) (gross)
  • ISBN 978-3-319-17807-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 149,99 €
price for China (P.R.) (gross)
  • ISBN 978-3-319-17806-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover 140,17 €
price for China (P.R.) (gross)
  • ISBN 978-3-319-38067-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Resistance of Cancer Cells to CTL-Mediated Immunotherapy
Editors
  • Benjamin Bonavida
  • Salem Chouaib
Series Title
Resistance to Targeted Anti-Cancer Therapeutics
Series Volume
7
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-17807-3
DOI
10.1007/978-3-319-17807-3
Hardcover ISBN
978-3-319-17806-6
Softcover ISBN
978-3-319-38067-4
Series ISSN
2196-5501
Edition Number
1
Number of Pages
XIX, 353
Number of Illustrations
11 b/w illustrations, 27 illustrations in colour
Topics