Editors:
- Describes the principles and practice of systematic reviews, meta-analysis, and evidence-based medicine.
- Explains the methodology of systematic review and meta-analysis of randomised, non-randomised, diagnostic test accuracy, and animal studies, as well as individual participant data meta-analysis and network meta-analysis.
- Written by clinicians, this reader friendly book will help readers in developing skills for using systematic reviews and meta-analyses as the best source of evidence for guiding clinical practice and research.
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Table of contents (17 chapters)
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Front Matter
About this book
Evidence based medicine is at the core of modern medicine. It involves the integration of individual clinical expertise with the best available clinical evidence from systematic research and patient's values and expectations. Systematic reviews offer a summary of the best available evidence. They are the most reliable and comprehensive statement about what works.
Written by clinical academics from Australia, UK, USA, and Switzerland, this contributed volume introduces the readers to the principles and practice of systematic reviews and meta-analysis. It covers the various steps involved in systematic reviews including development of a focused question and the strategy for conducting a comprehensive literature search, identifying studies addressing the underlying question, assessment of heterogeneity and the risk of bias in the included studies, data extraction, and the approach to meta-analysis. Crucial issues such as selecting the model for meta-analysis, generating and interpreting forest plots, assessing the risk of publication bias, cautions in the interpretation of subgroup and sensitivity analyses, rating certainty of the evidence using GRADE guideline, and standardized reporting of meta-analysis (PRISMA) are covered in detail. Every attempt is made to keep the narrative simple and clear. Mathematical formulae are avoided as much as possible.
While the focus of this book is on systematic reviews and meta-analyses of randomised controlled trials (RCTs), the gold standard of clinical research, the essentials of systematic reviews of non-RCTs, diagnostic test accuracy studies, animal studies, individual participant data meta-analysis, and network meta-analysis are also covered.
Readers from all faculties of medicine will enjoy this comprehensive and reader friendly book to understand the principles and practice of systematic reviews and meta-analysis for guiding their clinical practice and research.
Editors and Affiliations
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School of Medicine, University of Western Australia, Perth, Australia
Sanjay Patole
About the editor
Bibliographic Information
Book Title: Principles and Practice of Systematic Reviews and Meta-Analysis
Editors: Sanjay Patole
DOI: https://doi.org/10.1007/978-3-030-71921-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2021
Hardcover ISBN: 978-3-030-71920-3Published: 27 June 2021
Softcover ISBN: 978-3-030-71923-4Published: 28 June 2022
eBook ISBN: 978-3-030-71921-0Published: 26 June 2021
Edition Number: 1
Number of Pages: XII, 188
Number of Illustrations: 7 b/w illustrations, 52 illustrations in colour
Topics: Public Health, Statistics for Life Sciences, Medicine, Health Sciences