Practical Lymph Node and Bone Marrow Pathology

1. Front Matter

   Pages i-xiii

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2. Essentials of the Immune Response and Immunophenotyping

   • Chad M. McCall, Bethany D. Vallangeon, Anand Shreeram Lagoo

   Pages 1-14

3. Molecular Genetics and Cell Biology for Hematopathology

   • Linsheng Zhang

   Pages 15-34

4. Evaluation of Excised Lymph Nodes

   • Zenggang Pan, Le Aye, Imran N. Siddiqi, Endi Wang

   Pages 35-51

5. Lymphoid Pathology on Small Biopsies (FNA and Small Core) – Advantages and Limitations: Guidelines for Ancillary Studies According to Clinical Scenario and Morphology

   • Kathryn M. Hogan, Anand Shreeram Lagoo, Kedar V. Inamdar

   Pages 53-85

6. Small B-Cell Lymphomas With and Without Plasmacytic Differentiation

   • Juan Camilo Gómez-Gélvez, Kedar V. Inamdar

   Pages 87-121

7. Large B-Cell Lymphoma

   • Zenggang Pan

   Pages 123-155

8. High-Grade B-Cell Lymphoma

   • Xiaoqiong Wang, Qin Huang

   Pages 157-174

9. Major Subtypes of Mature T- and NK-Cell Neoplasms

   • Lina Irshaid, Mina L. Xu

   Pages 175-188

10. Hodgkin Lymphomas

    • Jinming Song, Shiyong Li

    Pages 189-208

11. Posttransplant Lymphoproliferative Disorders (PTLDs)

    • Jun Wang

    Pages 209-223

12. Immunodeficiency-Associated Lymphoproliferative Disorders Other Than PTLD (in Primary Immune Deficiency, HIV, and Iatrogenic Conditions)

    • Jerald Z. Gong, Siraj M. El Jamal, Guldeep Uppal

    Pages 225-251

13. Primary Extranodal Lymphomas of the GI Tract, Lung, CNS, and Skin with Common Mimics

    • Linlin Wang

    Pages 253-284

14. Lymphoid Neoplasms with “Benign” Clinical Course or Unclear Malignant Potential

    • Juehua Gao, Shunyou Gong

    Pages 285-293

15. B-Cell Lymphoma in Children or Pediatric Type

    • Shunyou Gong, Juehua Gao

    Pages 295-306

16. Indolent T-/NK-Cell Lymphoproliferative Disorders

    • Wenbin Xiao, Huan-You Wang

    Pages 307-321

17. Composite Lymphoma

    • Rohit Gulati, Jiehao Zhou

    Pages 323-344

18. Histiocytic/Dendritic Cell Neoplasms: Primary and Transdifferentiated

    • Chen Zhao, Zenggang Pan

    Pages 345-354

19. Typical Morphologic Patterns of Infectious and Other Reactive Lymphadenopathies

    • Maria (Ria) Vergara-Lluri, Rosemary She

    Pages 355-438

20. HHV8-Associated Lymphoproliferative Disorders

    • Wei Wang, L. Jeffrey Medeiros

    Pages 439-446

This book provides a step-by-step and practically applicable approach for the accurate and clinically relevant diagnosis of lymph node (LN) and bone marrow (BM) biopsies. Clinicians expect pathological guidance not only with accurate diagnosis, but also about disease progression, minimal residual disease, disease susceptibility to a particular therapy, effects of prior therapy on prognosis and subsequent therapy etc. This book provides brief but to the point guidance about the prognostic and therapeutic implications of key ancillary studies so that the pathologist is comfortable to answer clinician’s questions over the entire arc of manifestations and management of the disease. The text follows the WHO (2016) classification in essence but the material is organized in a fashion most useful to a practicing surgical pathologist. This is achieved by focusing on the morphological findings as the starting point. Using this morphological “backbone” and several frequently asked questions(FAQs) the reader is guided to a rational list of differential diagnoses leading to a definitive diagnosis. The contents of each chapter are carefully selected so that the practically important and directly applicable information is available in an easy-to-find and easy-to-grasp format.

Practical Lymph Node and Bone Marrow Pathology serves as a practical introduction and handbook for pathology trainees and hematopathology fellows and will remain a useful reference to practicing pathologists when they are signing out lymph nodes or bone marrow specimens.

• hematopathology
• Immunophenotyping
• Excisional biopsy
• lymphomas
• Plasma cell disorders
• surgical oncology

• Department of Pathology, Duke University School of Medicine and Duke Health System, Durham, USA

  Endi Wang, Anand Shreeram Lagoo

Endi Wang
Professor of Pathology, Pathology and Laboratory Medicine
Duke University School of Medicine
Durham, NC
USA


Anand Shreeram Lagoo
Professor of Pathology
Director, Hematopathology and Clinical Flow Cytometry
Duke University School of Medicine and Duke Health System
Durham, NC
USA

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