Authors:
- Nominated as an outstanding Ph.D. thesis by the University of Campinas, Brazil
- Presents an innovative approach, using gold chemistry to target zinc finger proteins
- Explores the use of Travelling-Wave Ion Mobility coupled with Mass Spectrometry, and X-ray Absorption Spectroscopy to obtain structural information on the Gold adducts
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (6 chapters)
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Front Matter
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Au(III) Complexes
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Front Matter
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About this book
This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.
Authors and Affiliations
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Institute of Chemistry, University of Campinas, Campinas, Brazil
Raphael Enoque Ferraz de Paiva
Bibliographic Information
Book Title: Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
Authors: Raphael Enoque Ferraz de Paiva
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-030-00853-6
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer Nature Switzerland AG 2018
Hardcover ISBN: 978-3-030-00852-9Published: 11 October 2018
Softcover ISBN: 978-3-030-13150-0Published: 10 December 2019
eBook ISBN: 978-3-030-00853-6Published: 01 October 2018
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XXXIX, 151
Number of Illustrations: 62 b/w illustrations, 38 illustrations in colour
Topics: Inorganic Chemistry, Organometallic Chemistry, Protein-Ligand Interactions, Mass Spectrometry, Bioorganic Chemistry, Immunology