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Prefoldins: the new chaperones

  • Book
  • © 2018

Overview

Editors:
  1. Nabil Djouder

    1. Centro Nacional de Investigaciones Oncológicas, CNIO, Spain

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  • A comprehensive book on molecular chaperones of the prefoldin family Several contributions from top researches in the prefoldin field Dedicated section to the URI prefoldin-like complex

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1106)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-ix
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  2. Functional Contributions of Prefoldin to Gene Expression

    • Laura Payán-Bravo, Xenia Peñate, Sebastián Chávez
    Pages 1-10

  3. Prefoldins in Archaea

    • Samuel Lim, Dominic J. Glover, Douglas S. Clark
    Pages 11-23

  4. Role of the PAQosome in Regulating Arrangement of Protein Quaternary Structure in Health and Disease

    • Marie-Soleil Gauthier, Philippe Cloutier, Benoit Coulombe
    Pages 25-36

  5. The Multiple Functions of the PAQosome: An R2TP- and URI1 Prefoldin-Based Chaperone Complex

    • Jeffrey Lynham, Walid A. Houry
    Pages 37-72

  6. Advances on the Structure of the R2TP/Prefoldin-like Complex

    • Hugo Muñoz-Hernández, Mohinder Pal, Carlos F. Rodríguez, Chrisostomos Prodromou, Laurence H. Pearl, Oscar Llorca
    Pages 73-83

  7. Role of the Unconventional Prefoldin Proteins URI and UXT in Transcription Regulation

    • Phillip A. Thomas, Paolo Mita, Susan Ha, Susan K. Logan
    Pages 85-94

  8. Roles and Functions of the Unconventional Prefoldin URI

    • Almudena Chaves-Pérez, Sebastian Thompson, Nabil Djouder
    Pages 95-108

  9. The Yeast Prefoldin Bud27

    • Verónica Martínez-Fernández, Ana Isabel Garrido-Godino, Abel Cuevas-Bermudez, Francisco Navarro
    Pages 109-118

  10. Structure and Function of the Cochaperone Prefoldin

    • Rocío Arranz, Jaime Martín-Benito, José M. Valpuesta
    Pages 119-131

  11. Back Matter

    Pages 133-135
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Keywords

About this book

This book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of prefoldins, some preliminary work suggests their contribution in assembly and activation of a variety of macromolecular complexes. Hence, the reader is introduced to recent structural findings via cryo-electron microscopy and to the importance of this particular group of proteins in health and disease.   This book also discusses the particular structure of the URI prefoldin-like complex. In addition, recent developments in the generation of URI mouse models speculate on the functions and emerging roles of the URI prefoldin-like complex in various cellular processes. This novel protein complex represents a unique cellular machinery, which molecular basis of its activity still remains to be determined.

This work is thus a guide to help researchers in the field to have a more comprehensive and critical view of the prefoldin world.

Editors and Affiliations

  • Centro Nacional de Investigaciones Oncológicas, CNIO, Spain

    Nabil Djouder

About the editor

Nabil Djouder obtained his PhD in Molecular Pharmacology from the University of Strasbourg (France) and the University of Freiburg (Germany). In 2001 he moved to Basel (Switzerland) as a postdoctoral research fellow and joined the laboratory of W. Krek at the Novartis Friedrich Miescher Institute. In 2003 he became a member of the Competence Centre for Systems Physiology and Metabolic Diseases (CCSPMD) and in September 2009 he joined the CNIO as a Principal Investigator establishing his group in the field of Growth factors, Metabolism and Cancer.

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