Nanotherapy for Brain Tumor Drug Delivery

1. Front Matter

   Pages i-xiii

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2. Glioblastoma: State of the Art of Treatments and Applications of Polymeric and Lipidic Nanomedicines

   • Valeria Sgarbi, Jason T. Duskey, Ilaria Ottonelli, Federica Da Ros, Natalia Oddone, Maria Angela Vandelli et al.

   Pages 1-61

3. Passive and Active Targeting of Brain Tumors

   • Amr Hefnawy, Ibrahim M. El-Sherbiny

   Pages 63-78

4. Strategies to Modulate the Blood-Brain Barrier for Directed Brain Tumor Targeting

   • Paula Schiapparelli, Montserrat Lara-Velazquez, Rawan Al-kharboosh, Hao Su, Honggang Cui, Alfredo Quinones-Hinojosa

   Pages 79-108

5. Drug Delivery Approaches and Imaging Techniques for Brain Tumor

   • Mark Bell, Christine Pujol Rooks, Vibhuti Agrahari

   Pages 109-126

6. Surface-Modified Nanodrug Carriers for Brain Cancer Treatment

   • Aniket S. Wadajkar, Nina P. Connolly, Christine P. Carney, Pranjali P. Kanvinde, Jeffrey A. Winkles, Graeme F. Woodworth et al.

   Pages 127-144

7. Inorganic Nanostructures for Brain Tumor Management

   • Mohd Imran, Awais Ahmed Abrar Ahmed, Babak Kateb, Ajeet Kaushik

   Pages 145-178

8. Strategies to Enhance the Distribution of Therapeutic Nanoparticles in the Brain by Convection Enhanced Delivery

   • Karina Negron, Namir Khalasawi, Jung Soo Suk

   Pages 179-204

9. Focused Ultrasound-Mediated Blood-Brain Barrier Disruption for Enhanced Drug Delivery to Brain Tumors

   • Pavlos Anastasiadis, Jeffrey A. Winkles, Anthony J. Kim, Graeme F. Woodworth

   Pages 205-223

10. Neurosurgical Implant-Based Strategy for Brain Cancer Therapy

    • Joshua Casaos, Noah Gorelick, Betty Tyler

    Pages 225-244

11. Liposome-Templated Hydrogel Nanoparticles for Targeted Delivery of CRISPR/Cas9 to Brain Tumors

    • Zeming Chen, Ann T. Chen, Jiangbing Zhou

    Pages 245-257

12. Methods to Separate, Characterize, and Encapsulate Drug Molecules into Exosomes for Targeted Delivery and Treatment of Glioblastoma

    • Yen Nguyen, Sandeep Kaur, Hae Shim, Vaibhav Mundra, Venkatareddy Nadithe

    Pages 259-279

13. Establishing Orthotopic Xenograft Glioblastoma Models for Use in Preclinical Development

    • João Basso, José Sereno, Ana Fortuna, Miguel Castelo-Branco, Carla Vitorino

    Pages 281-296

14. Back Matter

    Pages 297-298

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This volume provides a guide on nanoformulations and other drug delivery approaches for both academic and industry scientists. The chapters in this book cover diverse topics and techniques in nanoparticle drug delivery, gene therapy, neurosurgical brain implant, exosomes, MRI-guided focused ultrasound (MRgFUS), and advanced preclinical glioblastoma multiforme animal models. Some chapters discuss state-of-the-art and innovative nanomedicines for glioblastoma, surface-modified nanoparticle drug carriers for brain cancer treatment, focused ultrasound (FUS)-mediated blood-brain barrier disruption for enhanced drug delivery to brain tumors; gene therapy delivery approaches to treat brain cancer, and a liposome-template hydrogel nanoparticles (LHNPs) as a powerful CRISPR/Cas9 delivery vehicle. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. 


Cutting-edge and thorough, Nanotherapy for Brain Tumor Drug Delivery is a valuable resource for the scientific community working on this important therapeutic field, and will help fast-track the clinical translation of revolutionary nanotechnologies for treating brain tumors.    

• brain cancer
• malignant gliomas
• Nano-biotechnology
• stem cell
• molecular imaging

• CONRAD / Eastern Virginia Medical School, Arlington, USA

  Vivek Agrahari

• Department of Neurosurgery and Pharmacology, University of Maryland School of Medicine, Baltimore, USA

  Anthony Kim

• Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Science Center, Oklahoma City, USA

  Vibhuti Agrahari

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