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Diabetes Mellitus

A risk factor for Alzheimer's Disease

  • Book
  • © 2019

Overview

Editors:
  1. Yusaku Nakabeppu

    1. Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

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  2. Toshiharu Ninomiya

    1. Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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    You can also search for this editor in PubMed   Google Scholar

  • Describes in detail the mechanisms that make diabetes mellitus a risk factor for Alzheimer’s disease (AD)
  • Discusses the molecular interactions between diabetes and AD
  • Gives deep insights into AD treatment based on basic science

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1128)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-vi
    Download chapter PDF

  2. Origins of Brain Insulin and Its Function

    • Yusaku Nakabeppu
    Pages 1-11

  3. Epidemiological Evidence of the Relationship Between Diabetes and Dementia

    • Toshiharu Ninomiya
    Pages 13-25

  4. Molecular Pathophysiology of Insulin Depletion, Mitochondrial Dysfunction, and Oxidative Stress in Alzheimer’s Disease Brain

    • Yusaku Nakabeppu
    Pages 27-44

  5. The Full Spectrum of Alzheimer’s Disease Is Rooted in Metabolic Derangements That Drive Type 3 Diabetes

    • Suzanne M. de la Monte
    Pages 45-83

  6. The Roles of Apolipoprotein E, Lipids, and Glucose in the Pathogenesis of Alzheimer’s Disease

    • Mitsuru Shinohara, Naoyuki Sato
    Pages 85-101

  7. Molecular Connection Between Diabetes and Dementia

    • Yanxing Chen, Qian Yu, Cheng-Xin Gong
    Pages 103-131

  8. Type II Diabetes Mellitus Accelerates Age-Dependent Aβ Pathology in Cynomolgus Monkey Brain

    • Nobuyuki Kimura
    Pages 133-145

  9. Diabetes-Related Dementia

    • Haruo Hanyu
    Pages 147-160

  10. Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer’s Disease

    • Cristina Carvalho, Susana M. Cardoso, Sónia C. Correia, Paula I. Moreira
    Pages 161-183

  11. Mammalian Target of Rapamycin at the Crossroad Between Alzheimer’s Disease and Diabetes

    • Hanyu Liang, Jia Nie, Candice E. Van Skike, Joseph M. Valentine, Miranda E. Orr
    Pages 185-225

  12. Therapeutic Strategies for Alzheimer’s Disease in the View of Diabetes Mellitus

    • Yasumasa Ohyagi, Katsue Miyoshi, Norimichi Nakamura
    Pages 227-248
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Keywords

About this book

This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.



Editors and Affiliations

  • Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

    Yusaku Nakabeppu

  • Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Toshiharu Ninomiya

About the editors

Dr. Yusaku NakabeppuMedical Institute of Bioregulation, Kyushu University, Japan

Dr. Toshiharu Ninomiya
Dept. of Epidemiology and Public Health, Grad. School of Med. Sci., Kyushu Univ., Japan

Bibliographic Information

  • Book Title: Diabetes Mellitus

  • Book Subtitle: A risk factor for Alzheimer's Disease

  • Editors: Yusaku Nakabeppu, Toshiharu Ninomiya

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-981-13-3540-2

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2019

  • Hardcover ISBN: 978-981-13-3539-6Published: 15 May 2019

  • eBook ISBN: 978-981-13-3540-2Published: 06 May 2019

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VI, 248

  • Number of Illustrations: 21 b/w illustrations, 28 illustrations in colour

  • Topics: Neurosciences, Diabetes, Neurology

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