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  • © 2019

The Nociceptin/Orphanin FQ Peptide Receptor

  • Gives a comprehensive overview of research of the N/OFQ-NOP receptor system and biological actions of the NOP receptor
  • Illustrates the broad therapeutic potential of NOP receptor-targeted ligands
  • Contains in-depth reviews and exciting findings from leading scientists

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 254)

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  • Dispatched in 3 to 5 business days
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Table of contents (20 chapters)

  1. Front Matter

    Pages i-x
  2. The History of N/OFQ and the NOP Receptor

    • Rainer K. Reinscheid, Olivier Civelli
    Pages 3-16
  3. NOP-Targeted Peptide Ligands

    • Delia Preti, Girolamo Caló, Remo Guerrini
    Pages 17-36
  4. NOP-Targeted Nonpeptide Ligands

    • Nurulain T. Zaveri, Michael E. Meyer
    Pages 37-67
  5. Pharmacological Assays for Investigating the NOP Receptor

    • Davide Malfacini, Girolamo Caló
    Pages 69-89
  6. Electrophysiological Actions of N/OFQ

    • Bryony L. Winters, Macdonald J. Christie, Christopher W. Vaughan
    Pages 91-130
  7. NOP Receptor Signaling Cascades

    • Kyle E. Parker, Michael R. Bruchas
    Pages 131-139
  8. Regulation of the Genes Encoding the ppN/OFQ and NOP Receptor

    • Francesca Felicia Caputi, Patrizia Romualdi, Sanzio Candeletti
    Pages 141-162
  9. NOP-Related Mechanisms in Pain and Analgesia

    • Lawrence Toll, Akihiko Ozawa, Andrea Cippitelli
    Pages 165-186
  10. NOP-Related Mechanisms in Substance Use Disorders

    • Roberto Ciccocioppo, Anna Maria Borruto, Ana Domi, Koji Teshima, Nazzareno Cannella, Friedbert Weiss
    Pages 187-212
  11. NOP Receptor Ligands and Parkinson’s Disease

    • Daniela Mercatelli, Clarissa Anna Pisanò, Salvatore Novello, Michele Morari
    Pages 213-232
  12. NOP Ligands for the Treatment of Anxiety and Mood Disorders

    • Elaine C. Gavioli, Victor A. D. Holanda, Chiara Ruzza
    Pages 233-257
  13. N/OFQ-NOP System in Food Intake

    • Maria Vittoria Micioni Di Bonaventura, Emanuela Micioni Di Bonaventura, Carlo Cifani, Carlo Polidori
    Pages 279-295
  14. N/OFQ-NOP System in Peripheral and Central Immunomodulation

    • Salim Kadhim, Mark F. Bird, David G. Lambert
    Pages 297-311
  15. N/OFQ-NOP System and Airways

    • Bruno D’Agostino, Manuela Sgambato, Renata Esposito, Giuseppe Spaziano
    Pages 313-322
  16. Effects of NOP-Related Ligands in Nonhuman Primates

    • Norikazu Kiguchi, Mei-Chuan Ko
    Pages 323-343
  17. Nociceptin/Orphanin FQ and Urinary Bladder

    • Patrizia Angelico, Marco Barchielli, Massimo Lazzeri, Remo Guerrini, Girolamo Caló
    Pages 347-365
  18. Cebranopadol: A Novel First-in-Class Potent Analgesic Acting via NOP and Opioid Receptors

    • Thomas M. Tzschentke, Klaus Linz, Thomas Koch, Thomas Christoph
    Pages 367-398

About this book

The aim of this book is not only to introduce readers with a broad spectrum of biological actions of the NOP receptor, but also to feature a detailed look at the N/OFQ-NOP receptor system, medicinal chemistry, pharmacology, and clinical data of NOP-targeted ligands. This special volume book - for the first time focusing on the NOP receptor - is designed to serve as a useful reference, stimulate more research on the N/OFQ-NOP receptor system, and lead to more development of NOP-related ligands for several therapeutic applications.

Editors and Affiliations

  • Department of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston-Salem, USA

    Mei-Chuan Ko

  • Department of Medical Sciences, Section of Pharmacology, University of Ferrara, Ferrara, Italy

    Girolamo Caló

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access