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Methods in Molecular Biology

G Protein-Coupled Receptors in Drug Discovery

Methods and Protocols

Editors: Filizola, Marta (Ed.)

  • Includes cutting-edge methods and protocols on GPCRs in drug discovery
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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eBook $109.00
price for Brazil (gross)
  • ISBN 978-1-4939-2914-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for Brazil
  • ISBN 978-1-4939-2913-9
  • with online files
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for Brazil
  • ISBN 978-1-4939-4967-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.

Practical and fully updated, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets.

Table of contents (20 chapters)

  • Purification of Stabilized GPCRs for Structural and Biophysical Analyses

    Errey, James C. (et al.)

    Pages 1-15

  • Purification and Crystallization of a Thermostabilized Agonist-Bound Conformation of the Human Adenosine A2A Receptor

    Tate, Christopher G. (et al.)

    Pages 17-27

  • 2D Projection Analysis of GPCR Complexes by Negative Stain Electron Microscopy

    Peisley, Alys (et al.)

    Pages 29-38

  • Nuts and Bolts of CF3 and CH3 NMR Toward the Understanding of Conformational Exchange of GPCRs

    Prosser, R. Scott (et al.)

    Pages 39-51

  • Single-Molecule Fluorescence Microscopy for the Analysis of Fast Receptor Dynamics

    Wagner, Julia (et al.)

    Pages 53-66

Buy this book

eBook $109.00
price for Brazil (gross)
  • ISBN 978-1-4939-2914-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for Brazil
  • ISBN 978-1-4939-2913-9
  • with online files
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for Brazil
  • ISBN 978-1-4939-4967-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
G Protein-Coupled Receptors in Drug Discovery
Book Subtitle
Methods and Protocols
Editors
  • Marta Filizola
Series Title
Methods in Molecular Biology
Series Volume
1335
Copyright
2015
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-2914-6
DOI
10.1007/978-1-4939-2914-6
Hardcover ISBN
978-1-4939-2913-9
Softcover ISBN
978-1-4939-4967-0
Series ISSN
1064-3745
Edition Number
2
Number of Pages
XII, 327
Number of Illustrations
21 b/w illustrations, 50 illustrations in colour
Topics