Overview
- Explains the principles of the “state of life” in biological systems based on genome sequence information
- Bridges the gap between biological and physical sciences
- Explains the harmony of biological systems as a random process under constraint conditions
Part of the book series: Evolutionary Studies (EVOLUS)
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Table of contents (15 chapters)
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Front Matter
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The Big Question About Living Things
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Front Matter
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Diversity of Organisms in Real Space
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Front Matter
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Formation of Ordered Structure in Organisms by Random Mutations in Genome Sequences
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Front Matter
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Understanding Evolution Through the Phase Diagram of Life
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Front Matter
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Keywords
About this book
This book aims to understand biological evolution through a physical approach, focusing on the macroscopic aspects of the biological genome. Readers will discover the connection between genomic information and the harmony of biological systems, a relationship that remains elusive to many researchers in biological sciences.
The most common approach to understanding living organisms with physics is to begin with a single molecule of an organism. In contrast to this bottom-up approach, building from each molecule to the whole, this book takes a coarse-grained approach at the amino acid level to physically understand the macroscopic aspects of the organism. The book presents a system developed by the authors to predict membrane proteins with high accuracy using only physical parameters. Another distinctive perspective of this book is that it proposes the idea of a physical mechanism, other than natural selection, that orchestrates the emergence of order from random processes.The study of macroscopic aspects of living organisms based on this concept has parallels with thermostatistical mechanics for states of matter. Just as random processes create order in matter, there are physical random processes that form order in living organisms. This analogy is the central theme of the book.Using terms and analogies familiar to physicists, the book bridges the gap between biological and physical sciences. The book focuses on simple principles and is aimed primarily at researchers. While the content of this book is at the boundary area of biophysics, soft matter physics and bioinformatics, it will also be of interest to researchers and graduate students working on any biological topics.Authors and Affiliations
About the authors
Ryusuke Sawada has been an Assistant professor at the Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan, since 2022. His research interests include the biological evolution of genomes and protein sequences, and computational methods for drug development.
Bibliographic Information
Book Title: Evolution Seen from the Phase Diagram of Life
Authors: Shigeki Mitaku, Ryusuke Sawada
Series Title: Evolutionary Studies
DOI: https://doi.org/10.1007/978-981-97-0060-8
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024
Hardcover ISBN: 978-981-97-0059-2Published: 21 February 2024
Softcover ISBN: 978-981-97-0062-2Due: 15 April 2024
eBook ISBN: 978-981-97-0060-8Published: 20 February 2024
Series ISSN: 2509-484X
Series E-ISSN: 2509-4858
Edition Number: 1
Number of Pages: X, 144
Number of Illustrations: 1 b/w illustrations
Topics: Evolutionary Biology, Biological and Medical Physics, Biophysics, Bioinformatics