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Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders

  • Book
  • © 2023

Overview

Editors:
  1. Yong-Ku Kim

    1. Department of Psychiatry, Korea University Ansan Hospital, Ansan, Korea (Republic of)

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  • Examines interactions between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders
  • Considers the role of inflammation in numerous disorders
  • Examines potential new targets for prevention and treatment

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1411)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Rethinking and Paradigm Shift

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Neuron-Microglia Crosstalk in Neuropsychiatric Disorders

      • Sang Won Jeon, Yong-Ku Kim
      Pages 3-15

    3. Microbiota–Gut–Brain Axis: Pathophysiological Mechanism in Neuropsychiatric Disorders

      • Cheolmin Shin, Yong-Ku Kim
      Pages 17-37

    4. Inflammation-Mediated Responses in the Development of Neurodegenerative Diseases

      • Firzan Nainu, Sukamto S. Mamada, Harapan Harapan, Talha Bin Emran
      Pages 39-70

    5. Microbiome-Induced Autoimmunity and Novel Therapeutic Intervention

      • Alper Evrensel
      Pages 71-90

    6. Animal Inflammation-Based Models of Neuropsychiatric Disorders

      • Konstantin A. Demin, Konstantin A. Zabegalov, Tatiana O. Kolesnikova, David S. Galstyan, Yuriy M. H. B. Kositsyn, Fabiano V. Costa et al.
      Pages 91-104

    7. Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood

      • Sang Ho Shin, Yong-Ku Kim
      Pages 105-134

    8. C-Reactive Protein (CRP): A Potent Inflammation Biomarker in Psychiatric Disorders

      • Laura Orsolini, Simone Pompili, Umberto Volpe
      Pages 135-160

  3. Inflammation and Specific Disorders

    1. Front Matter

      Pages 161-161
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    2. Stress and Kynurenine-Inflammation Pathway in Major Depressive Disorder

      • Maiqueli Eduarda Dama Mingoti, Amanda Gollo Bertollo, Tácio de Oliveira, Zuleide Maria Ignácio
      Pages 163-190

    3. Glial-Neuronal Interaction in Synapses: A Possible Mechanism of the Pathophysiology of Bipolar Disorder

      • Krista M. Wartchow, Giselli Scaini, João Quevedo
      Pages 191-208

    4. Microbiota-Gut-Brain Axis in Major Depression: A New Therapeutic Approach

      • Il Bin Kim, Seon-Cheol Park, Yong-Ku Kim
      Pages 209-224

    5. PTSD, Immune System, and Inflammation

      • Nela Pivac, Barbara Vuic, Marina Sagud, Gordana Nedic Erjavec, Matea Nikolac Perkovic, Marcela Konjevod et al.
      Pages 225-262

    6. Sleep Immune Cross Talk and Insomnia

      • Marine Ambar Akkaoui, Laura Palagini, Pierre A. Geoffroy
      Pages 263-273

    7. Obsessive-Compulsive Disorder, PANDAS, and Tourette Syndrome: Immuno-inflammatory Disorders

      • Donatella Marazziti, Stefania Palermo, Alessandro Arone, Lucia Massa, Elisabetta Parra, Marly Simoncini et al.
      Pages 275-300

    8. Molecular Imaging of Neuroinflammation in Alzheimer’s Disease and Mild Cognitive Impairment

      • Junhyung Kim, Yong-Ku Kim
      Pages 301-326

    9. A Potential Role for Neuroinflammation in ADHD

      • Daniela Vázquez-González, Sonia Carreón-Trujillo, Lourdes Alvarez-Arellano, Daniela Melissa Abarca-Merlin, Pablo Domínguez-López, Marcela Salazar-García et al.
      Pages 327-356

    10. A Link Between Inflammatory Mechanisms and Fibromyalgia

      • Ashika Bains, Samuel Kohrman, Diana Punko, Gregory Fricchione
      Pages 357-378

    11. Suicide and Inflammation

      • Jennifer J. Donegan, Charles B. Nemeroff
      Pages 379-404
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Keywords

About this book

This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.

Editors and Affiliations

  • Department of Psychiatry, Korea University Ansan Hospital, Ansan, Korea (Republic of)

    Yong-Ku Kim

About the editor

Yong-Ku Kim, MD, PhD is a Professor of Psychiatry at College of Medicine, Korea University. He received a MD degree from College of Medicine, Korea University in 1987 and a PHD in psychiatry from Korea University in 1998. Dr. Kim has been affiliated with Korea University since 1998, first as an assistant professor (1998-2000), then as associated professor (2001-2005), professor (2006- present). For the past 20 years, his professional activities have extended beyond the area of pure clinical or research work. Dr. Kim has well over 200 publications in peer-reviewed international journals, including Biological Psychiatry, Molecular Psychiatry, Clinical Journal of Psychiatry, and Progress in Neuropsychopharmacology and Biological Psychiatry and 30 publications of book chapters and have made over 90 academic presentations in my area of interest. Dr. Kim is a fellow of Collogicum Internationale Neuropsychopharmacologicum, International Society for Affective Disorders, World Federation of theSociety of biological Psychiatry. He currently sits on the editorial boards of some leading academic journals in the field of neurobiology, including Progress in Neuropsychopharmacology and Biological Psychiatry, Psychiatry Investigation, World Journal Psychiatry, Annals of Depression and Anxiety, Psychiatry Journal and so on. Dr. Kim received prestigious awards such as Astrageneca Award and Dr. Paul Janssen Schizophrenia Research Award. Dr. Kim is currently the president of Korean society of Biological Psychiatry (2016-present). 

Bibliographic Information

  • Book Title: Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders

  • Editors: Yong-Ku Kim

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-981-19-7376-5

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023

  • Hardcover ISBN: 978-981-19-7375-8Published: 23 March 2023

  • Softcover ISBN: 978-981-19-7378-9Published: 10 April 2024

  • eBook ISBN: 978-981-19-7376-5Published: 22 March 2023

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVII, 554

  • Number of Illustrations: 8 b/w illustrations, 20 illustrations in colour

  • Topics: Neurosciences, Immunology, Physiology, Neuropsychology, Psychiatry

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