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  • © 2020

Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers

  • Summarizes the recent advances in potential cancer diagnostic markers in gastrointestinal cancers
  • Examines the molecular markers, metabolic markers, circulatory biomarkers, and genetic susceptibility markers in GI cancers
  • Discusses the role of GWAS, big data analytics, computation biology, and systems biology in identifying novel biomarkers
  • Reviews the use of nanosensors, and electrochemical, optical and DNA biosensors for analyzing markers of GI cancer

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xxiii
  2. Emerging Biomarkers for Gastrointestinal Cancer

    1. Front Matter

      Pages 1-1
    2. Biomarkers as the Promising Tools for Early Detection of Gastrointestinal Cancer

      • Pallaval Veera Bramhachari, Nageswara Rao Reddy Neelapu
      Pages 15-25
    3. Development and Evaluation of Biomarkers for Early Detection of Cancer

      • Surekha Challa, Ravi Chandra Pavan Kumar Sri-Tirumala-Peddiniti, Nageswara Rao Reddy Neelapu
      Pages 27-43
    4. Prognostic Molecular Markers for Gastrointestinal Cancer

      • Achanta Jagadeesh, G. Mohana Sheela, B. Pratap Naidu, Pallaval Veera Bramhachari
      Pages 45-53
    5. Metabolic Markers for Early Detection of Gastrointestinal Cancers

      • A. M. V. N. Prathyusha, B. Prathap Naidu, Pallaval Veera Bramhachari
      Pages 55-71
    6. Current Status of MicroRNA-Based Biomarkers for Gastric Cancer

      • Prakash C. Sharma, Renu Verma
      Pages 73-91
    7. Genetic Susceptibility Markers of Gastrointestinal Cancer

      • M. Kiran Kumar, Pola Sudhakar
      Pages 93-115
    8. Overview of Early Detection of Gastrointestinal Cancer

      • Pola Sudhakar, Pavani Sanapala, B. Pratap Naidu
      Pages 117-129
  3. Advances in Biosensors and Detection Technologies for Gastrointestinal Cancer

    1. Front Matter

      Pages 131-131
    2. Biosensors and its Applications for Early Detection of Gastrointestinal Cancer

      • Deepthi Nammi, Nageswara Rao Reddy Neelapu
      Pages 133-168
    3. Application of Nanotechnology in Early Detection of Gastrointestinal Cancer

      • Nageswara Rao Reddy Neelapu, Deepthi Nammi
      Pages 169-187
  4. Computational Methods for Identification Gastrointestinal Cancer Biomarkers and Early Diagnosis of GI Cancer

    1. Front Matter

      Pages 189-189
    2. Genetic Marker Identification for the Detection of Early-Onset Gastric Cancer Through Genome-Wide Association Studies

      • Manoj Kumar Gupta, Jinka Rajeswari, Pamuru Ramachandra Reddy, Koppula Satish Kumar, K. V. Chamundeswaramma, Ramakrishna Vadde
      Pages 191-211
    3. Big Data Analytics and Radiomics to Discover Diagnostics and Therapeutics for Gastric Cancer

      • Kummetha Jagadish, B. Pratap Naidu, G. Mohana Sheela, Nageswara Rao Reddy Neelapu, Pallaval Veera Bramhachari
      Pages 213-219

About this book

This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer.

The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancertreatment.

The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.

Editors and Affiliations

  • Department of Biotechnology, Krishna University, Machilipatnam, India

    Pallaval Veera Bramhachari

  • Department of Biochemistry and Bioinformatics, GITAM Institute of Science, Gandhi Institute of Technology and Management (GITAM) (Deemed-to-be-University), Visakhapatnam, India

    Nageswara Rao Reddy Neelapu

About the editors

Dr. Pallaval Veera Bramhachari is currently Head of the Department of Biotechnology at Krishna University, India. He has served as a Postdoctoral Research Scientist at the Bacterial Pathogenesis Laboratory, Queensland Institute of Medical Research (QIMR), Australia, and DBT Postdoctoral Fellow at the Department of Microbiology and Cell Biology, Indian Institute of Science (IIsc), Bangalore. He holds a Ph.D. in Microbiology from Goa University, India. His major research focuses on applied microbiology and cell biology research, including biochemical mechanism of bacterial-biofilm formations, structure-function relationship of bacterial rhamnolipids, and basic and translational cancer research. He has published more than 115 research articles in leading peer-reviewed international journals, and 3 international books and has presented 47 abstracts at various national and international conferences. He has served as an editorial board member and reviewer for a number of national andinternational journals. He is a member of several international scientific societies and organizations, most importantly, Indian Science Congress & Society of Biological Chemists, India. He has received a number of various prestigious awards, notably, AP State Best Scientist Award 2017, DST SERB Young Scientist Award (2011) and nominated as an Associate Fellow of Andhra Pradesh Academy of Sciences (APAS) for the year 2016.

Dr. Neelapu Nageswara Rao Reddy is currently an Assistant Professor at the Department of Biochemistry and Bioinformatics, Institute of Science, Gandhi Institute of Technology and Management (GITAM) (deemed university), India. He obtained his Master’s in Life Science from Pondicherry Central University, and Ph.D. in Evolutionary Bioinformatics from Andhra University, Visakhapatnam, India. His research interests include bioinformatics, cancer, and fungal biology with specialization in drug target discovery, HLA-based peptide vaccine design, genome analysis, phylogenyand evolution. Furthermore, he has expanded his research fields to understanding biochemical mechanisms of stress-induced proteins, structure-function relationship of proteins, and exploring next generation sequencing data to understand traits. He has been a recipient of several fellowships, like CSIR-UGC Junior Research Fellowship; and DAAD Visiting Fellowship, Germany. He has published more than 50 research articles in prestigious peer-reviewed international journals and presented 18 abstracts at various national and international conferences. He has served on the editorial board for a number of national and international journals, and is a member of several international scientific societies and organizations, most importantly, Indian Science Congress & Society of Biological Chemists, India.

Bibliographic Information

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access