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Mechanically Gated Channels and their Regulation

  • Book
  • © 2012

Overview

Editors:
  1. Andre Kamkin

    1. Chemical Department, Moscow State University, Moscow, Russia

  2. Ilya Lozinsky

    1. , Fundamental and Applied Physiology, Russian State Medical University, Moscow, Russia

  • One book provides a detailed description of molecular mechanisms of mechanosensing and mechanotransduction in different cells.
  • One book brings together a comprehensive outline of modern vision of structure and functions of mechanically gated channels.
  • It provides a wide and detailed description of various signaling pathways, which contribute to mechanosensitity and mechanotrasduction.
  • Includes supplementary material: sn.pub/extras
  • Includes supplementary material: sn.pub/extras

Part of the book series: Mechanosensitivity in Cells and Tissues (MECT, volume 6)

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  • 6 Citations

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About this book

The volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. In our opinion the book presents not only the latest achievements in the field but also brings the problem closer to the experts in related medical and biological sciences as well as practicing doctors. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different living organs and tissues and allows to predict changes, which arise due to alterations of their environment, and possibly will allow to develop new methods of artificial intervention. We also hope that presenting the problem will attract more attention to it both from researchers and practitioners and will assist to efficiently introduce it into the practical medicine.

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Table of contents (15 chapters)

  1. Front Matter

    Pages 1-1
    Download chapter PDF

  2. Force from Lipids: A Multidisciplinary Approach to Study Bacterial Mechanosensitive Ion Channels

    • Charles G. Cranfield, Anna Kloda, Takeshi Nomura, Evgeny Petrov, Andrew Battle, Maryrose Constantine et al.
    Pages 1-33

  3. Mechanosensitive K2P channels, TREKking through the autonomic nervous system

    • J. Antonio Lamas
    Pages 35-68

  4. TRPV1 in Cell Signaling: Molecular Mechanisms of Function and Modulation

    • Tamara Rosenbaum, Andrés Jara-Oseguera
    Pages 69-102

  5. The Molecular Mechanism of Multifunctional Mechano-Gated Channel TRPV4

    • Makoto Suzuki, Astuko Mizuno
    Pages 103-157

  6. Mechanical Stretch and Intermediate-Conductance Ca2+-Activated K+ Channels in Arterial Smooth Muscle Cells

    • Yasunobu Hayabuchi, Miho Sakata, Tatsuya Ohnishi, Shoji Kagami
    Pages 159-187

  7. Sensing Mechanism of Stretch Activated Ion Channels

    • Naomi Niisato, Yoshinori Marunaka
    Pages 189-213

  8. Ion Channels in Cardiac Fibroblasts: Link to Mechanically Gated Channels and their Regulation

    • Denis V. Abramochkin, Ilya Lozinsky, Andre Kamkin
    Pages 215-244

  9. The Role of Nitric Oxide in the Regulation of Ion Channels in the Cardiomyocytes: Link to Mechanically Gated Channels

    • Ekaterina Yu. Makarenko, Ilya Lozinsky, Andre Kamkin
    Pages 245-262

  10. The Role of Ion Channels in Cellular Mechanotransduction of Hydrostatic Pressure

    • Kevin D. Champaigne, Jiro Nagatomi
    Pages 263-279

  11. Lipid-Mediated Mechanisms Involved in the Mechanical Activation of TRPC6 and TRPV4 Channels in the Vascular Tone Regulation

    • Ryuji Inoue, Yaopeng Hu, Yubin Duan, Kyohei Itsuki
    Pages 281-301

  12. Stretch Effects on Atrial Conduction: A Potential Contributor to Arrhythmogenesis

    • Michela Masè, Flavia Ravelli
    Pages 303-325

  13. Early Activation of Intracellular Signals after Myocardial Stretch: Anrep Effect, Myocardial Hypertrophy and Heart Failure

    • Horacio E. Cingolani, María C. Villa-Abrille, Claudia I. Caldiz, Irene L. Ennis, Oscar H. Cingolani, Patricio E. Morgan et al.
    Pages 327-365

  14. Recent Aspects of Angiotensin II Action in the Heart. Implications for Myocardial Ischemia and Heart Failure

    • Walmor C. De Mello
    Pages 367-378

  15. Mechanosensitivity of Pancreatic β-cells, Adipocytes, and Skeletal Muscle Cells: The Therapeutic Targets of Metabolic Syndrome

    • Koichi Nakayama, Yoshiyuki Tanabe, Kazuo Obara, Tomohisa Ishikawa
    Pages 379-404

  16. The Role of the Primary Cilium in Chondrocyte Response to Mechanical Loading

    • Angus K. T. Wann, Clare Thompson, Martin M. Knight
    Pages 405-426

  17. Back Matter

    Pages 420-420
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Editors and Affiliations

  • Chemical Department, Moscow State University, Moscow, Russia

    Andre Kamkin

  • , Fundamental and Applied Physiology, Russian State Medical University, Moscow, Russia

    Ilya Lozinsky

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