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HMG-CoA Reductase Inhibitors

  • Book
  • © 2002

Overview

Editors:
  1. Gerd Schmitz

    1. Institute for Clinical Chemistry and Laboratory Medicine, University Regensburg, Regensburg, Germany

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  2. Michael Torzewski

    1. Johannes Gutenberg-Universität Mainz Klinikum, Institut für Klinische Chemie und Laboratoriumsmedizin, Mainz, Germany

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Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (8 chapters)

  1. Front Matter

    Pages I-X
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  2. History and development of HMG-CoA reductase inhibitors

    • Stefano Bellosta, Rodolfo Paoletti, Alberto Corsini
    Pages 1-17

  3. Structure and mechanisms of action of HMG-CoA reductase inhibitors

    • Margaret E. Brousseau, Ernst J. Schaefer
    Pages 19-34

  4. Sterol-regulatory element binding proteins (SREBPs): gene-regulatory target of statin action

    • Jörg Kotzka, Wilhelm Krone, Dirk Müller-Wieland
    Pages 35-54

  5. Cellular effects of HMG-CoA reductase inhibitors on blood cells (monocytes, macrophages, platelets)

    • Gerd Schmitz, Michael Torzewski
    Pages 55-80

  6. Pleiotropic effects of HMG-CoA reductase inhibitors on cells of the vascular wall

    • Koichi Node, James K. Liao
    Pages 81-98

  7. Indications and contra-indications for statin treatment (primary and secondary prevention of hypercholesterolemia)

    • Hans-P. Thomas, Elisabeth Steinhagen-Thiessen
    Pages 99-120

  8. Clinical experience: studies with HMG-CoA reductase inhibitors

    • Helena K. Gylling, Tatu A. Miettinen
    Pages 121-133

  9. Cost-effectiveness of statins in primary and secondary prevention of coronary heart disease

    • Colin Berry, Andrew Davie, John McMurray
    Pages 135-147

  10. Back Matter

    Pages 149-151
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Keywords

About this book

HMG-CoA reductase inhibitors (statins) are established drugs for the treatment of hypercholesterolemia. Furthermore, they induce regression of vascular atherosclerosis as well as reduction of cardiovascular-related morbidity and death in patients with and without coronary artery disease. This book deals with statins which have substantially altered the approach to therapy of atherosclerosis and its sequelae. Emphasis is placed on the scientific background to the discoveries and the development of the therapy, including an overview of the current state of knowledge of the drugs. Clinical data are reviewed extensively. This book not only provides the reader with valuable information but also stimulates further research into the pathogenesis of atherosclerosis and the mechanisms behind the action of effective statins. It sets the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating atherosclerosis and its sequelae. This topical volume...

Editors and Affiliations

  • Institute for Clinical Chemistry and Laboratory Medicine, University Regensburg, Regensburg, Germany

    Gerd Schmitz

  • Johannes Gutenberg-Universität Mainz Klinikum, Institut für Klinische Chemie und Laboratoriumsmedizin, Mainz, Germany

    Michael Torzewski

Bibliographic Information

  • Book Title: HMG-CoA Reductase Inhibitors

  • Editors: Gerd Schmitz, Michael Torzewski

  • Series Title: Milestones in Drug Therapy

  • DOI: https://doi.org/10.1007/978-3-0348-8135-7

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 2002

  • Hardcover ISBN: 978-3-7643-6307-9Published: 23 October 2002

  • Softcover ISBN: 978-3-0348-9451-7Published: 30 October 2012

  • eBook ISBN: 978-3-0348-8135-7Published: 06 December 2012

  • Series ISSN: 2296-6056

  • Series E-ISSN: 2296-6064

  • Edition Number: 1

  • Number of Pages: X, 151

  • Topics: Pharmacy

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