Skip to main content
SpringerLink
Log in

Acute Leukemias V

Experimental Approaches and Management of Refractory Disease

  • Conference proceedings
  • © 1996

Overview

Editors:
  1. W. Hiddemann

    1. Department of Internal Medicine, University of Göttingen, Göttingen, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. W. Plunkett

    1. Department of Internal Medicine, University of Göttingen, Göttingen, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. T. Büchner

    1. Department of Internal Medicine, University of Münster, Münster, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  4. J. Ritter

    1. Department of Pediatric Oncology, University of Münster, Münster, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  5. B. Wörmann

    1. Department of Internal Medicine, MD Anderson Cancer Center, Houston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  6. M. J. Keating

    1. Department of Internal Medicine, MD Anderson Cancer Center, Houston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  7. U. Creutzig

    1. Koordinierungsstelle, Deutsche Krebsgesellschaft e.V., Hannover, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Haematology and Blood Transfusion Hämatologie und Bluttransfusion (HAEMATOLOGY, volume 37)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (105 papers)

  1. Front Matter

    Pages I-XXVI
    Download chapter PDF

  2. Leukemia Cell Biology

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Cell Differentiation and Programmed Cell Death: A New Approach to Leukemia Therapy

      • Leo Sachs
      Pages 3-10

    3. CD34 and CD38 Expression on Blasts in Myelodysplastic Syndromes and Secondary AML

      • W. Verbeek, C. Ries, D. Grove, M. Unterhalt, W. Hiddemann, B. Wörmann
      Pages 11-14

    4. Heterogeneity of HRX-FEL Fusion Transcripts in Adult and Pediatric t(4;11) ALL

      • F. Griesinger, T. Jahn, H. Elfers, W.-D. Ludwig, M. Falk, H. Rieder et al.
      Pages 15-21

  3. Pharmacokinetics — Clinical Implications

    1. Front Matter

      Pages 23-23
      Download chapter PDF

    2. Fludarabine and Ara-C Combination for Treatment of Adult Acute Myelogenous Leukemia: Pharmacokinetic and Pharmacodynamic Effects

      • Varsha Gandhi, Min Du, Amy J. Chapman, Peng Huang, Elihu Estey, Michael J. Keating et al.
      Pages 25-31

    3. Pharmacokinetics of Ara-CMP-Stearate (YNK01) — Phase I Study of the Oral Ara-C Derivative

      • Jan Braess, Eberhard Schleyer, Bernhard Ramsauer, Michael Unterhalt, Cornelia Kaufmann, Sabine Wilde et al.
      Pages 32-40

    4. Differential Effect of GM-CSF on the Intracellular Ara-C Metabolism in Normal Bone Marrow Mononuclear Cells and Acute Myeloid Leukemia (AML) Blasts

      • Christoph Reuter, Claus Rolf, Eberhard Schleyer, Michael Unterhalt, Bernhard Woermann, Thomas Buechner et al.
      Pages 41-49

    5. Intracellular Retention of Cytosine-Arabinoside-Triphosphate in Leukemic Blast Cells from Children

      • J. Boos, M. Schiller, B. Pröbsting, U. Creutzig, J. Ritter
      Pages 50-53

    6. The Pharmacokinetics of Epipodopyllotoxins — Clinical Relevance

      • K. B. Mross
      Pages 54-61

    7. Targeted Drug Therapy in Childhood Acute Lymphoblastic Leukemia

      • Mary V. Relling, Ching-Hon Pui, William E. Evans
      Pages 62-66

    8. Asparagine Levels in Children on E. Coli- and Erwinia-Asparaginase Therapy

      • J. Boos, G. Werber, E. Verspohl, E. Ahlke, U. Nowak-Göttl, H. Jürgens
      Pages 67-69

  4. Chemo-Resistance

    1. Front Matter

      Pages 71-71
      Download chapter PDF

    2. Pharmacologic Modulation of Multidrug Resistance in Acute Leukemia: Results and Challenges

      • Alan F. List, Betty Glinsmann-Gibson, William S. Dalton
      Pages 73-78

    3. Kinetic Resistance, Regrowth Resistance, and Multidrug Resistance in the Treatment of Acute Myelogenous Leukemia (AML)

      • Harvey D. Preisler, Azra Raza
      Pages 79-88

    4. Topoisomerases — from Basic Research to Clinical Implications

      • Frank Gieseler
      Pages 89-93

    5. Mechanisms of Acquired ARA-C and DAC Resistance in Acute Myeloid Leukemia (AML): Development of a Model for the Study of Mutational Loss of Deoxycytidine Kinase (DCK) Activity

      • A. P. A. Stegmann, M. W. Honders, J. E. Landegent, R. Willemze
      Pages 94-100

    6. Expression of P-Glycoprotein in Children and Adults with Leukemia — Correlation with Clinical Outcome

      • Slawomir Kaczorowski, Maria Ochocka, Robert Aleksandrowicz, Maria Kaczorowska, Michal Matysiak, Marek Karwacki
      Pages 101-107

    7. Multidrug Resistance in Acute Myelogenous Leukemia: Relevance to Clinical and Laboratory Data

      • Andrey Zaritskey, Irina Stuf, Tatyana Bykova, Kirill Titov, Nadezhda Medvedeva, Natalya Anikina et al.
      Pages 108-111
Back to top

Keywords

About this book

150 years after the first description of the clinical picture of "white blood" and the introduction of the term "leukemia" by R. Virchow it appears, that the leukemias, and the acute leukemias in particular, serve as an impressive example for the major improvements that have been achieved in the treatment but also in the understand­ ing of the biology of malignant dis orders. The international symposia "Acute Leukemia" which are held at Münster since 1986 have developed into an interna­ tional forum to review the current progress and the future perspectives of leukemia research and therapy at a high scientific and clinicallevel. Since the possibility for active participation in these symposia is somewhat restricted we are glad to have the opportunity to extend the information that was presented at the symposium "Acute Leukemias V - Experimental Approaches and Management of Refractory Disease" which was held from February 27 to March 2, 1994 to a broader audience of basic scientists and clinicians. This meeting was especiaIly designed to discuss experimen­ tal approaches and the management of refractory disease which allows to evaluate new experimental therapies on the basis of preclinical studies.

Editors and Affiliations

  • Department of Internal Medicine, University of Göttingen, Göttingen, Germany

    W. Hiddemann, W. Plunkett

  • Department of Internal Medicine, University of Münster, Münster, Germany

    T. Büchner

  • Department of Pediatric Oncology, University of Münster, Münster, Germany

    J. Ritter

  • Department of Internal Medicine, MD Anderson Cancer Center, Houston, USA

    B. Wörmann, M. J. Keating

  • Koordinierungsstelle, Deutsche Krebsgesellschaft e.V., Hannover, Germany

    U. Creutzig

Bibliographic Information

  • Book Title: Acute Leukemias V

  • Book Subtitle: Experimental Approaches and Management of Refractory Disease

  • Editors: W. Hiddemann, W. Plunkett, T. Büchner, J. Ritter, B. Wörmann, M. J. Keating, U. Creutzig

  • Series Title: Haematology and Blood Transfusion Hämatologie und Bluttransfusion

  • DOI: https://doi.org/10.1007/978-3-642-78907-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1996

  • Softcover ISBN: 978-3-642-78909-0Published: 01 December 2012

  • eBook ISBN: 978-3-642-78907-6Published: 17 April 2013

  • Series ISSN: 0440-0607

  • Edition Number: 1

  • Number of Pages: XXVI, 613

  • Number of Illustrations: 54 b/w illustrations

  • Topics: Hematology, Oncology

Publish with us

Policies and ethics

Back to top

Search

Navigation