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Human Tumour Xenografts in Anticancer Drug Development

  • Conference proceedings
  • © 1988

Overview

Editors:
  1. Benjamin Winograd

    1. EORTC New Drug Development Office, Free University Hospital, Amsterdam, The Netherlands

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  2. Michael Peckham

    1. Central Office, British Postgraduate Medical Federation, London, UK

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  3. Herbert Michael Pinedo

    1. Department of Oncology, Free University Hospital, Amsterdam, The Netherlands

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Part of the book series: ESO Monographs (ESO MONOGRAPHS)

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Table of contents (36 papers)

  1. Front Matter

    Pages I-XV
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  2. Biological Behaviour of Human Tumours Transplanted in Mice and the Evaluation of Therapeutic Response

    1. Front Matter

      Pages 1-1
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    2. The Therapeutic Response of a Variety of Human Tumour Xenografts

      • G. G. Steel, M. J. Peckham
      Pages 3-9

    3. Biology of Human Ovarian Cancer Xenografts

      • E. Boven
      Pages 11-13

    4. Representativity of Xenografts for Clinical Cancer. Tumor and Host Characteristics as Variables of Tumor Take Rate

      • Ø. Fodstad
      Pages 15-21

  3. Prediction of Tumour Response for the Individual Patient by the Human Tumour Xenograft

    1. Front Matter

      Pages 23-23
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    2. Comparison of Tumor Response in Nude Mice and in Patients

      • H. H. Fiebig
      Pages 25-30

  4. Prediction of Antitumour Activity per Tumour Type by the Human Tumour Xenograft

    1. Front Matter

      Pages 31-31
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    2. Conventional Agents in Human Ovarian Cancer Xenografts

      • E. Boven
      Pages 33-35

    3. Activity of Conventional Drugs in Head and Neck Cancer Xenografts

      • B. J. M. Braakhuis, G. B. Snow
      Pages 37-39

    4. Preclinical Drug Evaluation with Human Melanoma Xenografts

      • R. Osieka
      Pages 41-46

    5. Lung Xenografts as a Predictive Screen for Antineoplastic Agents

      • J. Mattern, K. Wayss, M. Volm
      Pages 47-50

    6. Chemotherapy Studies in Human Non-Small Cell Lung Cancer Xenografts Transplanted in Immune-Deprived Mice

      • J. Carmichael, J. F. Smyth
      Pages 51-55

    7. Establishment and Response to Chemotherapy of Human Cervical Carcinoma Xenografts

      • L. R. Kelland, K. S. Tonkin
      Pages 57-62

    8. The Usefulness of the Nude Mouse Model for Predicting the Chemosensitivity of Human Tumors. Studies in Malignant Melanoma

      • Ø. Fodstad, S. Aamdal, A. Pihl
      Pages 63-67

  5. Preclinical Evaluation of Analogs of Known Anticancer Agents

    1. Front Matter

      Pages 69-69
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    2. Screening of Analogs in Human Ovarian Cancer Xenografts

      • E. Boven
      Pages 71-73

    3. Predictability of Clinical Response of Several Human and Murine Tumor Models to Four Anthracycline Derivatives

      • G. Pezzoni, F. C. Gluliani
      Pages 75-78

  6. New Drugs

    1. Front Matter

      Pages 79-79
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    2. Activity of Six New Drugs in Head and Neck Cancer Xenografts

      • B. J. M. Braakhuis, A. Leyva, H. M. Pinedo, G. B. Snow
      Pages 81-83
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Keywords

About this book

Starting in 1986, the European School of Oncology has expanded its activities in post­ graduate teaching, which consisted mainly of traditional disease-orientated courses, by promoting new educational initiatives. One of these is the cloister seminars, short meet­ ings intended for highly qualified oncologists and dealing with specific, controversial aspects of clinical practice and research. Another is the institution of permanent study groups, also called task forces, where a limited number of leading experts are invited to meet once a year with the aim of defining the state of the art and possibly reaching a consensus on developments and treatment in specific fields of oncology. This series of ESO Monographs was designed with the specific purpose of disseminat­ ing the results of the most interesting of the seminars and study groups, and providing concise and updated reviews of the subjects discussed. It was decided to keep the layout very simple in order to keep costs to a minimum and make the monographs available in the shortest possible time, thus overcoming a com­ mon problem in medical literature: that of the material being outdated even before publication. Umberto Veronesi Chairman, Scientific Committee European School of Oncology Position Paper on the Application of Human Tumour Xenografts as a Model for Preclinical Phase" Studies in the Evaluation of New Anticancer Compounds Outcome of a seminar on Human Tumour Xenografts organised by the European School of Oncology, Milan, 26th-27th May, 1986.

Editors and Affiliations

  • EORTC New Drug Development Office, Free University Hospital, Amsterdam, The Netherlands

    Benjamin Winograd

  • Central Office, British Postgraduate Medical Federation, London, UK

    Michael Peckham

  • Department of Oncology, Free University Hospital, Amsterdam, The Netherlands

    Herbert Michael Pinedo

Bibliographic Information

  • Book Title: Human Tumour Xenografts in Anticancer Drug Development

  • Editors: Benjamin Winograd, Michael Peckham, Herbert Michael Pinedo

  • Series Title: ESO Monographs

  • DOI: https://doi.org/10.1007/978-3-642-73252-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1988

  • Softcover ISBN: 978-3-642-73254-6Published: 06 January 2012

  • eBook ISBN: 978-3-642-73252-2Published: 11 November 2013

  • Edition Number: 1

  • Number of Pages: XV, 143

  • Number of Illustrations: 4 b/w illustrations

  • Topics: Pharmacology/Toxicology, Oncology, Biochemistry, general, Allergology, Immunology, Pharmacy

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