RNA Metabolism in Trypanosomes

1. Front Matter

   Pages i-vi

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2. RNA Polymerases and Transcription Factors of Trypanosomes

   • Arthur Günzl

   Pages 1-27

3. SL RNA Biogenesis in Kinetoplastids: A Long and Winding Road

   • Nancy R. Sturm, Jesse R. Zamudio, David A. Campbell

   Pages 29-47

4. Pre-mRNA Splicing in Trypanosoma brucei: Factors, Mechanisms, and Regulation

   • Christian Preußer, Nicolas Jaé, Arthur Günzl, Albrecht Bindereif

   Pages 49-77

5. mRNA Turnover in Trypanosomes

   • Christine Clayton

   Pages 79-97

6. tRNA Biogenesis and Processing

   • Jessica L. Spears, Mary Anne T. Rubio, Paul J. Sample, Juan D. Alfonzo

   Pages 99-121

7. rRNA Biogenesis in Trypanosomes

   • Shulamit Michaeli

   Pages 123-148

8. RNA Editing in African Trypanosomes: A U-ser’s G-U-ide

   • H. Ulrich Göringer

   Pages 149-165

9. The RNA Interference Pathway in Trypanosoma brucei

   • Elisabetta Ullu, Nikolay G. Kolev, Rebecca L. Barnes, Christian Tschudi

   Pages 167-185

10. Translation in Trypanosomatids

    • Michal Shapira, Alexandra Zinoviev

    Pages 187-214

11. Mitochondrial Translation in Trypanosomatids

    • Dmitri A. Maslov, Rajendra K. Agrawal

    Pages 215-236

12. RNA-Seq Analysis of the Transcriptome of Trypanosoma brucei

    • Jan Mani, Kapila Gunasekera, Isabel Roditi

    Pages 237-265

13. Back Matter

    Pages 267-271

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Trypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene expression and regulation, which benefit enormously from the trypanosome genome projects and from the new genome-wide approaches recently introduced in trypanosome research. This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses. Recent progress in RNA-focused research in trypanosomatids promises to yield novel insights into trypanosome-specific features, as well as to reveal in the process new potential therapeutic strategies for combating these parasitic diseases.

• Gene Expression
• Molecular Biology
• RNA
• RNA Metabolism
• RNA Polymerase
• Trypanosomes

• , Department of Biology and Chemistry, Justus Liebig University of Giessen, Giessen, Germany

  Albrecht Bindereif

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