Overview
- Gives comprehensive, up-to-date overview on the major groups of ribonucleases
- Puts latest knowledge about ribonucleases into a wider context, such as medical applications
- Written by international experts
- Includes supplementary material: sn.pub/extras
Part of the book series: Nucleic Acids and Molecular Biology (NUCLEIC)
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Table of contents (15 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Ribonucleases are a ubiquitous and functionally diverse group of enzymes that have a common ability to cleave RNA. Either through scission of internal phosphodiesters, or removal of nucleotides from RNA 5’ or 3’ ends, ribonucleases perform essential roles in gene expression and regulation, genome replication and maintenance, host defense, stress response, and viral strategies of infection. Ribonucleases have also served as highly informative models to understand virtually every aspect of biomolecular structure and function. The fifteen chapters in this volume are written by recognized researchers in the field, and provide in-depth analyses of the major ribonuclease families. Particular focus is given to the relation of ribonuclease structure and mechanism to biological function, as well as ribonuclease dysfunction in certain disease states. Other topics include the evolutionary genetics and functional diversification of ribonucleases, engineered ribonucleases as anti-cancer agents, the mechanisms of action of artificial ribonucleases, and ribonucleases as models to understand protein folding and stability. This volume should serve as an essential reference for a broad range of researchers and educators with interests in RNA metabolism, enzymology, and gene regulation.
Editors and Affiliations
Bibliographic Information
Book Title: Ribonucleases
Editors: Allen W. Nicholson
Series Title: Nucleic Acids and Molecular Biology
DOI: https://doi.org/10.1007/978-3-642-21078-5
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2011
Hardcover ISBN: 978-3-642-21077-8Published: 06 October 2011
Softcover ISBN: 978-3-642-27090-1Published: 26 November 2013
eBook ISBN: 978-3-642-21078-5Published: 06 October 2011
Series ISSN: 0933-1891
Series E-ISSN: 1869-2486
Edition Number: 1
Number of Pages: XIV, 406
Topics: Enzymology, Nucleic Acid Chemistry, Cell Biology, Molecular Medicine