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Advances in Eicosanoid Research

  • Conference proceedings
  • © 2000

Overview

Editors:
  1. C. N. Serhan

    1. Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. H. D. Perez

    1. Dept. of Immunology, Berlex Biosciences, Richmond, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 31)

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Table of contents (10 papers)

  1. Front Matter

    Pages I-XII
    Download chapter PDF

  2. The Mechanism of Action of Anti-Inflammatory Drugs

    • J. R. Vane
    Pages 1-23

  3. Human Group-V Phospholipase-A2 Expression in Pichia pastoris and Its Role in Eicosanoid Generation

    • L. J. Lefkowitz, H. Shinohara, E. A. Dennis
    Pages 25-52

  4. Fatty-Acid Substrate Interactions with Cyclo-oxygenases

    • W. L. Smith, C. J. Rieke, E. D. Thuresson, A. M. Mulichak, R. M. Garavito
    Pages 53-64

  5. Structure, Function and Inhibition of Cyclo-oxygenases

    • L. J. Marnett
    Pages 65-83

  6. Leukotriene-A4 Hydrolase: Probing the Active Sites and Catalytic Mechanisms by Site-Directed Mutagenesis

    • J. Z. Haeggström, A. Wetterholm
    Pages 85-96

  7. The Regulation of Cyclooxygenase-1 and -2 in Knockout Cells and Cyclooxygenase and Fever in Knockout Mice

    • L. R. Ballou
    Pages 97-124

  8. Leukotriene-B4 Receptor and Signal Transduction

    • T. Shimizu, T. Yokomizo, T. Izumi
    Pages 125-141

  9. Lipoxins, Aspirin-Triggered 15-epi-Lipoxin Stable Analogs and Their Receptors in Anti-Inflammation: A Window for Therapeutic Opportunity

    • C. N. Serhan, B. D. Levy, C. B. Clish, K. Gronert, N. Chiang
    Pages 143-185

  10. Lipoxin-Stable Analogs: Potential Therapeutic Downregulators of Intestinal Inflammation

    • A. T. Gewirtz, J. L. Madara
    Pages 187-199

  11. The Role of Eicosanoids in Tumor Growth and Metastasis

    • D. Nie, K. Tang, K. Szekeres, M. Trikha, K. V. Honn
    Pages 201-217

  12. Back Matter

    Pages 219-225
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Keywords

About this book

Over the last few years, we have witnessed tremendous progress in the field of eicosanoids and their therapeutic applications. Receptor an­ tagonists for leukotrienes have been tested as anti-inflammatories and are on the market as a treatment for asthma. Receptor agonists for pro­ stacyclin are being tested for the treatment of peripheral vascular dis­ ease, and selective inhibitors of cyclooxygenase type II were just ap­ proved for the treatment of rheumatoid arthritis. All these developments are the culmination of many years and man-hours of careful research. The field has now entered an upswing that will result in novel thera­ peutic applications within the next 10 years. New molecules and me­ diators have been identified, new enzymes and pathways elucidated and new therapeutic approaches have emerged. The concept of ei­ cosanoids as "pro-inflammatory" molecules is being challenged, and their role as regulators is increasingly recognized. In fact, some of these molecules may be important endogenous anti-inflammatory agents.

Editors and Affiliations

  • Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA

    C. N. Serhan

  • Dept. of Immunology, Berlex Biosciences, Richmond, USA

    H. D. Perez

Bibliographic Information

  • Book Title: Advances in Eicosanoid Research

  • Editors: C. N. Serhan, H. D. Perez

  • Series Title: Ernst Schering Foundation Symposium Proceedings

  • DOI: https://doi.org/10.1007/978-3-662-04047-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2000

  • Hardcover ISBN: 978-3-540-66747-6Due: 10 April 2000

  • Softcover ISBN: 978-3-662-04049-2Published: 06 December 2012

  • eBook ISBN: 978-3-662-04047-8Published: 14 March 2013

  • Series ISSN: 0947-6075

  • Edition Number: 1

  • Number of Pages: XII, 225

  • Number of Illustrations: 36 b/w illustrations

  • Topics: Biochemistry, general, Biotechnology, Immunology

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