Catalytic RNA

1. Front Matter

   Pages I-XIII

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2. Group I Ribozymes: Substrate Recognition, Catalytic Strategies, and Comparative Mechanistic Analysis

   • T. R. Cech, D. Herschlag

   Pages 1-17

3. Dynamics of a Group I Ribozyme Detected by Spectroscopic Methods

   • D. H. Turner, Y. Li, M. Fountain, L. Profenno, P. C. Bevilacqua

   Pages 19-32

4. The Structure of Group I Ribozymes

   • L. Jaeger, F. Michel, E. Westhof

   Pages 33-51

5. Interaction of Aminoglycoside Antibiotics with RNA

   • R. Schroeder, U. von Ahsen

   Pages 53-74

6. Catalytic Reaction Mechanisms and Structural Features of Group II Intron Ribozymes

   • A. M. Pyle

   Pages 75-107

7. Structural Analysis of the Bacterial Ribonuclease P RNA

   • J. M. Nolan, N. R. Pace

   Pages 109-128

8. Structural Analysis and Modifications of the Hairpin Ribozyme

   • J. M. Burke, S. E. Butcher, B. Sargueil

   Pages 129-143

9. Circular RNAs: Generation of Small RNAs with Unique Properties by Splicing Permuted Intron-Exon Sequences

   • M. D. Been, M. Puttaraju

   Pages 145-159

10. Three-Dimensional Structure of the Hammerhead Ribozyme

    • D. B. McKay

    Pages 161-172

11. The Hammerhead Ribozyme

    • J. B. Thomson, T. Tuschl, F. Eckstein

    Pages 173-196

12. Probing the Cleavage Activity of the Hammerhead Ribozyme Using Analog Complexes

    • R. G. Kuimelis, L. W. McLaughlin

    Pages 197-215

13. Mechanistic Studies on Hammerhead Ribozymes

    • P. K. R. Kumar, D. M. Zhou, K. Yoshinari, K. Taira

    Pages 217-230

14. Hammerhead Ribozymes with Long Flanking Sequences: a Structural and Kinetic View

    • G. Sczakiel

    Pages 231-242

15. Design, Synthesis, and Function of Therapeutic Hammerhead Ribozymes

    • N. Usman, D. T. Stinchcomb

    Pages 243-264

16. Synthetic Catalytic Oligonucleotides Based on the Hammerhead Ribozyme

    • B. S. Sproat

    Pages 265-281

17. Efficacy of Hammerhead Ribozymes Targeting α-Lactalbumin Transcripts: Experiments in Cells and Transgenic Mice

    • P. J. L’Huillier

    Pages 283-300

18. Anti-HIV Therapeutic Hammerhead Ribozymes: Targeting Strategies and Optimization of Intracellular Function

    • E. Bertrand, J. Rossi

    Pages 301-313

19. Inhibition of HIV Replication by the Hairpin Ribozyme

    • P. J. Welch, A. Hampel, J. Barber, F. Wong-Staal, M. Yu

    Pages 315-327

20. The Use of Ribozymes to Inhibit HIV Replication

    • L.-Q. Sun, W. L. Gerlach, G. Symonds

    Pages 329-342

In recent years, unprecedented advances in many aspects of the molecular biology of nucleic acids have been witnessed. The area of RNA chemistry has undergone a kind of explosion, with a huge interest in RNA-mediated catalysis. At the same time, our structural understanding of DNA-protein interactions has increased enormously, and the related area of RNA-protein interactions is beginning to gather pace. This softcover edition from the successful series Nucleic Acids and Molecular Biology is devoted to the structure and mechanism of ribozymes, and their potential exploitation. The subject has both important evolutionary implications and potential practical application in the development of therapeutic agents for diseases such as AIDS.

• AIDS
• HIV
• Nucleotide
• RNA
• biology
• catalysis
• chemistry
• fungi
• genetics
• molecular biology
• molecular genetics
• nucleic acid
• protein
• ribozyme
• synthesis

"This collection will provide a valuable resource to beginning investigators and to the general scientist who has kept abreast of the field to date." Cell
"This volume is a rich source of information on catalytic RNA, with many of the major players contributing articles." Nature

• Max-Planck-Institut für Experimentelle Medizin, Göttingen, Germany

  Fritz Eckstein

• Biochemistry Department, University of Dundee, Dundee, UK

  David M. J. Lilley

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