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Sex Steroids and the Cardiovascular System

  • Conference proceedings
  • © 1992

Overview

Editors:
  1. Peter W. Ramwell

    1. Department of Physiology and Biophysics, Georgetown University Medical Center, USA

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  2. Gabor M. Rubanyi
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  3. Ekkehard Schillinger
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Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 5)

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Table of contents (12 papers)

  1. Front Matter

    Pages I-XII
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  2. Cardiovascular Sexual Dimorphism

    • Peter W. Ramwell, Estelle Ramey
    Pages 1-7

  3. Sexual Dimorphism of Cardiovascular Function: The Role of Androgens

    • Jürgen Bachmann, Ursula Ganten, Günter Stock, Detlev Ganten
    Pages 9-30

  4. Sexual Dimorphism in the Cardiovascular Actions of Vasopressin

    • Leonard Share, Joan T. Crofton
    Pages 31-51

  5. Cardiovascular Adaptation to Pregnancy

    • Mark J. Morton
    Pages 53-64

  6. Oral Contraceptives and Thrombotic Risk: A Critical Overview

    • Eberhard F. Mammen
    Pages 65-93

  7. Studies on the Mechanisms of Action of Steroids on Coagulation and Fibrinolysis

    • Cees Kluft, Jan A. Gevers Leuven, Frans M. Helmerhorst
    Pages 95-110

  8. Can Animal Models Be Used to Predict the Hemostasiologic Effect of Steroid Hormones in Man?

    • Andreas Süßmilch, Rupprecht Zierz, Karsten Parczyk, Krzystof Chwalisz, Karl-Heinrich Fritzemeier, Berthold Baldus
    Pages 111-128

  9. Estradiol and Myointimal Proliferation

    • Marie L. Foegh
    Pages 129-137

  10. Modulation of the Extracellular Matrix by Sex Steroids

    • Hermann Graf
    Pages 139-144

  11. Vascular Non-genomic Effects of Estrogen

    • Michel Farhat, Sylvie Abi-Younes, Roberto Vargas, Raymond M. Wolfe, Robert Clarke, Peter W. Ramwell
    Pages 145-159

  12. Effects of Estrogens and Progestins on Atherosclerosis in Primates

    • Michael R. Adams, Janice D. Wagner, Thomas B. Clarkson
    Pages 161-175

  13. A Review of the Epidemiology of Postmenopausal Estrogens and the Risk of Coronary Heart Disease

    • Meir J. Stampfer
    Pages 177-197

  14. Back Matter

    Pages 199-201
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Keywords

About this book

Evidence accumulated over the past decade show that gonadal steroid hormones participate in an important way in the physiological and pa­ thophysiological regulation of the cardiovascular system. The hor­ monal profile appears to put males at a disadvantage biologically in terms of cardiovascular diseases. The incidence of hypertension is higher in men than in pre-monopausal women indicating an influence of gender on the hypertensive disease process. Males and females have equivalent cholesterol levels until puberty but males suffer an ex­ ponential increase in heart disease in their forties, while the female rise does not start until a decade later, after menopause. Animal and human studies provided ample evidence, that estrogens lower the levels of low density lipoproteins and keep high density lipoproteins elevated. These changes may be advantageous in the prevention of heart diesease. Co­ ronary artery atherosclerosis has been shown to be more pronounced in ovarectomized female monkeys as in intact females. Androgen, con­ versely, lowers the high density lipoproteins and elevates low density lipoproteins. Regarding blood pressure, it is well established that hypertension is more severe or develops more rapidly in male than fe­ male rats in several genetic forms of hypertension, and that gonadal steroid hormones are probably playing an important role in explaining this observation. Risk factors of human hypertension and coronary heart dies ease include menopause and ovarectomy.

Editors and Affiliations

  • Department of Physiology and Biophysics, Georgetown University Medical Center, USA

    Peter W. Ramwell

Bibliographic Information

  • Book Title: Sex Steroids and the Cardiovascular System

  • Editors: Peter W. Ramwell, Gabor M. Rubanyi, Ekkehard Schillinger

  • Series Title: Ernst Schering Foundation Symposium Proceedings

  • DOI: https://doi.org/10.1007/978-3-662-02764-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1992

  • Softcover ISBN: 978-3-662-02766-0Published: 14 November 2012

  • eBook ISBN: 978-3-662-02764-6Published: 06 December 2012

  • Series ISSN: 0947-6075

  • Edition Number: 1

  • Number of Pages: XII, 201

  • Number of Illustrations: 26 b/w illustrations

  • Topics: Cardiology, Endocrinology

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