Skip to main content
  • Book
  • © 2005

Homing Endonucleases and Inteins

  • First book devoted exclusively to the biology and technical applications growing out of research with inteins and homing endonucleases
  • Includes supplementary material: sn.pub/extras

Part of the book series: Nucleic Acids and Molecular Biology (NUCLEIC, volume 16)

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (20 chapters)

  1. Front Matter

    Pages I-XIX
  2. The LAGLIDADG Homing Endonuclease Family

    • Brett Chevalier, Raymond J. Monnat Jr., Barry L. Stoddard
    Pages 33-47
  3. HNH Endonucleases

    • Anthony H. Keeble, María J. Maté, Colin Kleanthous
    Pages 49-65
  4. GIY-YIG Homing Endonucleases — Beads on a String

    • Patrick Van Roey, Victoria Derbyshire
    Pages 67-83
  5. His-Cys Box Homing Endonucleases

    • Eric A. Galburt, Melissa S. Jurica
    Pages 85-102
  6. Group I Introns and Their Maturases: Uninvited, but Welcome Guests

    • Mark G. Caprara, Richard B. Waring
    Pages 103-119
  7. Function and Evolution of HO and VDE Endonucleases in Fungi

    • James E. Haber, Kenneth H. Wolfe
    Pages 161-175
  8. Inteins — A Historical Perspective

    • Francine B. Perler
    Pages 193-210
  9. Origin and Evolution of Inteins and Other Hint Domains

    • Bareket Dassa, Shmuel Pietrokovski
    Pages 211-231
  10. Biochemical Mechanisms of Intein-Mediated Protein Splicing

    • Kenneth V. Mills, Henry Paulus
    Pages 233-255
  11. The Structure and Function of Intein-Associated Homing Endonucleases

    • Carmen M. Moure, Florante A. Quiocho
    Pages 257-271
  12. Harnessing Inteins for Protein Purification and Characterization

    • Shaorong Chong, Ming-Qun Xu
    Pages 273-292
  13. Production of Cyclic Proteins and Peptides

    • Ali Tavassoli, Todd A. Naumann, Stephen J. Benkovic
    Pages 293-305
  14. Inteins for Split-Protein Reconstitutions and Their Applications

    • Takeaki Ozawa, Yoshio Umezawa
    Pages 307-323
  15. Intein Reporter and Selection Systems

    • David W. Wood, Georgios Skretas
    Pages 325-344

About this book

This book provides the first and only comprehensive description and detailed summary of the genetics, structure, function, mechanisms of action, evolution and engineering of homing endonucleases and inteins. These two unique protein superfamilies, which are tied together through their frequent fusion and coevolution, have generated considerable excitement for their fundamental, structural, and functional properties, their evolution as parasitic elements, and their widespread applications as gene targeting agents and as instruments for the generation of modified proteins and novel protein combinations.

Editors and Affiliations

  • Wadsworth Center/NYSDOH, Center for Medical Science, Albany, USA

    Marlene Belfort, Victoria Derbyshire

  • Dept. of Chemical Engineering, Princeton University, Princeton, USA

    David W. Wood

  • Fred Hutchinson Cancer Research, Center Institute, Seattle, USA

    Barry L. Stoddard

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access