ADP-Ribosylation of Proteins

1. Front Matter

   Pages I-XXI

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2. ADP-Ribosylation and Regulation of Cellular Function

   1. Front Matter

      Pages 1-1

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   2. Multiple Aspects of ADP-Ribosylation Reactions

      • Paul Mandel

      Pages 2-8

   3. ADP-Ribosylation as a Cellular Control Mechanism

      • Sydney Shall

      Pages 9-29

3. Poly(ADP-Ribose): Structure and Enzymology

   1. Front Matter

      Pages 31-31

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   2. Size Distribution of Branched Polymers of ADP-Ribose Generated in Vitro and in Vivo

      • Rafael Alvarez-Gonzales, Myron K. Jacobson

      Pages 32-36

   3. Studies on the Structure of Poly(ADP-Ribose) by HPLC. Separation of in Vitro Generated Polymer Chains, Analysis of Chain Length, and Branching

      • Alaeddin Hakam, Ernest Kun

      Pages 37-40

   4. Probable Helical Conformation of Poly(ADP-Ribose)

      • Takeyoshi Minaga, Ernest Kun

      Pages 41-46

   5. Immobilized Poly(ADP-Ribose) Synthetase: Preparation and Properties

      • Kunihiro Ueda, Jingyuan Zhang, Osamu Hayaishi

      Pages 47-51

   6. The Domain Structure of Poly(ADP-Ribose) Synthetase and Its Role in Accurate Transcription Initiation

      • Yutaka Shizuta, Isamu Kameshita, Michiko Agemori, Hiroshi Ushiro, Taketoshi Taniguchi, Masahiko Otsuki et al.

      Pages 52-59

   7. DNA-Poly(ADP-Ribose) Polymerase Complex: Isolation of the DNA Wrapping the Enzyme Molecule

      • Marie E. Ittel, Jenny Jongstra-Bilen, Claude Niedergang, Paul Mandel, Etienne Delain

      Pages 60-68

   8. The Role of Lysine Residues in the Catalytic Function and DNA Binding of Poly(ADP-Ribose) Polymerase as Determined by the Covalent Modification of the Enzyme Protein with Methyl Acetimidate

      • Pal I. Bauer, Ernest Kun

      Pages 69-73

   9. ADP-Ribosyltransferase from Hen Liver Nuclei: Purification, Properties, and Evidence for ADP-Ribosylation-Induced Suppression of Cyclic AMP-Dependent Phosphorylation

      • Makoto Shimoyama, Yoshinori Tanigawa, Takahisa Ushiroyama, Mikako Tsuchiya, Ryoji Matsuura

      Pages 74-81

   10. Poly(ADP-Ribos)ylation of Nuclear Enzymes

       • Koichiro Yoshihara, Asako Itaya, Yasuharu Tanaka, Yasuhiro Ohashi, Kimihiko Ito, Hirobumi Teraoka et al.

       Pages 82-92

   11. Kinetic Mechanism of Poly(ADP-Ribose) Polymerase

       • Robert C. Benjamin, Paul F. Cook, Myron K. Jacobson

       Pages 93-97

   12. Specificity of Poly(ADP-Ribose) Synthetase Inhibitors

       • Michael R. Purnell, William R. Kidwell, Lindsay Minshall, William J. D. Whish

       Pages 98-105

   13. Inhibition of ADP-Ribosylation Reaction by 2′, 5′-Oligoadenylates

       • Enzo Leone, Hisanori Suzuki, Benedetta Farina, Arman D. Pivazian, Marat Ya Karpeisky

       Pages 106-110

   14. Activity Gels of Poly(ADP-Ribose) Polymerase: Phylogenetic Studies and Variations in Human Blood Cells

       • Anna I. Scovassi, Elisabetta Franchi, Paola Isernia, Ercole Brusamolino, Miria Stefanini, Umberto Bertazzoni

       Pages 111-115

   15. The Relationship Between DNA Strand Breaks and ADP-Ribosylation

       • Christopher J. Skidmore, Janet Jones, Janet M. Oxberry, Elizabeth Chaudun, Marie-France Counis

       Pages 116-123

   16. Mechanism of Ethanol Stimulation of Poly(ADP-Ribose) Synthetase

       • James L. Sims, Robert C. Benjamin

       Pages 124-128

This book provides an update on recent advances in the field of ADP­ ribosylation reactions. The individual chapters represent the synopses of contributions which were presented at the Seventh International Symposium on ADP-Ribosylation Reactions, held in Vitznau, Switzer­ land, from September 23 to 27, 1984. This volume covers new devel­ opments in the field since the last meeting was held on this topic in 1982, in Tokyo. Therefore, the present text is not meant to form a comprehensive account of a specialized research area, but encompasses a collection of state-of-the-art reports from the vast majority of laboratories currently involved in ADP-ribosylation work. For the sake of rapid publication, the editorial policy was to ensure easy accessibility of information contained in individual articles rather than to provide elaborate cross references or reference to work published prior to 1982. However, a detailed subject index will help the reader find complementary information. The enzymes of ADP-ribose metabolism have not yet acquired universally acceptable trivial names and the Enzyme Commission has not yet defmitely decided on formal appellations. Consequently, a variety of names for the nuclear enzyme appear in this book, including nuc1ear(ADP-ribosyl)transferase, poly(ADP-ribose) polymerase, or synthetase or synthase. Hopefully, a common convention will soon be established. The Seventh International Symposium on ADP-Ribosylation Reac­ tions was only possible because of the generous support which we have been given by our sponsors, listed below.

• Calcium
• DNA
• Nucleotide
• cancer
• cell
• cell culture
• cell death
• cellular differentiation
• enzyme
• enzymes
• gene expression
• metabolism
• mutation
• protein
• transcription

• Institut für Pharmakologie und Biochemie, Veterinärmedizinische Fakultät der Universität, Zürich, Switzerland

  Felix R. Althaus

• Physiologisch-chemisches Institut, Universität Hamburg, Hamburg 20-40, Germany

  Helmuth Hilz

• The University of Sussex, Brighton, Sussex, England

  Sydney Shall

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