Skip to main content
SpringerLink
Log in
Book cover

Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins

  • Book
  • © 2017

Overview

Editors:
  1. Ulf Grawunder

    1. NBE-Therapeutics Ltd., Basel, Switzerland

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Stefan Barth

    1. Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Offers cutting-edge information on the development of antibody drug conjugates and recombinant immunotoxins
  • Explores related basic biological and chemical technologies and promotes new developments toward clinical applications
  • Primarily aimed at postgraduate students, researchers and clinicians

Part of the book series: Milestones in Drug Therapy (MDT)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (8 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Chemical Assembly of Antibody-Drug Conjugates

    • Alex R. Nanna, William R. Roush, Christoph Rader
    Pages 1-28

  3. Preclinical Evaluation of ADCs Delivering Highly Potent Pyrrolobenzodiazepine (PBD) Dimers

    • John A. Hartley
    Pages 29-46

  4. Stable and Homogeneous Drug Conjugation by Sequential Bis-Alkylation at Disulphide Bonds Using Bis-Sulphone Reagents

    • Martin Pabst, Matthew Bird, Mark Frigerio, Antony Godwin
    Pages 47-67

  5. Calicheamicin Antibody-Drug Conjugates for Liquid and Solid Tumor Indications

    • Hans-Peter Gerber, Marc Damelin, Puja Sapra
    Pages 69-84

  6. Enzyme-Based Strategies to Generate Site-Specifically Conjugated Antibody Drug Conjugates

    • Roger R. Beerli, Ulf Grawunder
    Pages 85-106

  7. Substance P–Saporin for the Treatment of Intractable Pain

    • Hugh Nymeyer, Douglas A. Lappi, Denise Higgins, Carl E. Noe, Arthur E. Frankel
    Pages 107-130

  8. Recombinant Immunotoxins for Chronic Inflammatory Disease

    • Theo Thepen, Stefan Barth
    Pages 131-150

  9. BL22: A Milestone in Targeting CD22

    • Robert J. Kreitman, David J. P. FitzGerald, Ira Pastan
    Pages 151-176

  10. Back Matter

    Pages 177-181
    Download chapter PDF
Back to top

Keywords

About this book

This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.

The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.

Reviews









Editors and Affiliations

  • NBE-Therapeutics Ltd., Basel, Switzerland

    Ulf Grawunder

  • Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

    Stefan Barth

Bibliographic Information

  • Book Title: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins

  • Editors: Ulf Grawunder, Stefan Barth

  • Series Title: Milestones in Drug Therapy

  • DOI: https://doi.org/10.1007/978-3-319-46877-8

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-46875-4Published: 18 April 2017

  • Softcover ISBN: 978-3-319-83609-6Published: 18 July 2018

  • eBook ISBN: 978-3-319-46877-8Published: 07 April 2017

  • Series ISSN: 2296-6056

  • Series E-ISSN: 2296-6064

  • Edition Number: 1

  • Number of Pages: XI, 181

  • Number of Illustrations: 18 b/w illustrations, 39 illustrations in colour

  • Topics: Pharmacology/Toxicology, Antibodies, Pharmacotherapy, Cancer Research, Oncology

Publish with us

Policies and ethics

Back to top

Search

Navigation