Editors:
- Describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies
- Includes the important topics at the frontier of this field
- Written by important scientists in the field
- Includes supplementary material: sn.pub/extras
Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials (SMTEB, volume 16)
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Table of contents (12 chapters)
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Front Matter
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Back Matter
About this book
This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases.
There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.
Editors and Affiliations
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Department of Biomedical Engineering, Tel Aviv University Faculty of Engineering, Tel Aviv, Israel
Amit Gefen
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Dept. of Cell and Developmental Biology Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
Dafna Benayahu
Bibliographic Information
Book Title: The Mechanobiology of Obesity and Related Diseases
Editors: Amit Gefen, Dafna Benayahu
Series Title: Studies in Mechanobiology, Tissue Engineering and Biomaterials
DOI: https://doi.org/10.1007/978-3-319-09336-9
Publisher: Springer Cham
eBook Packages: Engineering, Engineering (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2015
Hardcover ISBN: 978-3-319-09335-2Published: 04 November 2014
Softcover ISBN: 978-3-319-37626-4Published: 10 September 2016
eBook ISBN: 978-3-319-09336-9Published: 18 October 2014
Series ISSN: 1868-2006
Series E-ISSN: 1868-2014
Edition Number: 1
Number of Pages: X, 296
Topics: Biomedical Engineering and Bioengineering, Cell Physiology, Biological and Medical Physics, Biophysics, Biomaterials