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Inhibitors of Monoamine Oxidase B

Pharmacology and Clinical Use in Neurodegenerative Disorders

  • Book
  • © 1993

Overview

Editors:
  1. I. Szelenyi

    1. Dept. of Pharmacology, ASTA Medica AG, Frankfurt/Main 1, Germany

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Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Parkinson’s Disease: A Brief Introduction

    1. Front Matter

      Pages 1-1
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    2. Anatomy of the Human Basal Ganglia

      • H. Braak, E. Braak
      Pages 3-23

    3. The Pathophysiological Basis of Parkinson’s Disease

      • M. Gerlach, P. Riederer
      Pages 25-50

    4. Parkinson’s Disease and Its Existing Therapy

      • P.-A. Fischer
      Pages 51-71

  3. Chemistry and Pharmacology of Monoamine Oxidase B Inhibitors

    1. Front Matter

      Pages 73-73
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    2. Medicinal Chemistry of Present and Future MAO-B Inhibitors

      • J. Gaál, I. Hermecz
      Pages 75-108

    3. l-Deprenyl: A Unique MAO-B Inhibitor

      • E. E. Polymeropoulos
      Pages 109-124

    4. Pharmacology of Monoamine Oxidase Type B Inhibitors

      • K. Magyar
      Pages 125-143

    5. The Pharmacological Basis of the Therapeutic Effect of (—)-Deprenyl in Age-Related Neurological Diseases

      • J. Knoll
      Pages 145-168

    6. Neurotoxins and Monoamine Oxidase B Inhibitors: Possible Mechanisms for the Neuroprotective Effect of (—)-Deprenyl

      • V. Glover, M. Sandler
      Pages 169-181

    7. The Mode of Action of MAO-B Inhibitors

      • M. Gerlach, P. Riederer, M. B. H. Youdim
      Pages 183-200

    8. Pharmacokinetics and Clinical Pharmacology of Selegiline

      • E. H. Heinonen, M. I. Anttila, R. A. S. Lammintausta
      Pages 201-213

    9. Preclinical Evaluation of l-Deprenyl: Lack of Amphetamine-Like Abuse Potential

      • S. Yasar, G. Winger, B. Nickel, G. Schulze, S. R. Goldberg
      Pages 215-233

  4. Clinical Experience with Monoamine Oxidase B Inhibitors

    1. Front Matter

      Pages 235-235
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    2. The History of l-Deprenyl

      • M. J. Parnham
      Pages 237-251

    3. MAO-B Inhibitors in Neurological Disorders with Special Reference to Selegiline

      • K. Wessel
      Pages 253-275

    4. (—)-Deprenyl Combined with L-Dopa in the Treatment of Parkinson’s Disease

      • T. S. Elizan
      Pages 277-288

    5. Neuroprotective Effects of MAO-B Inhibition: Clinical Studies in Parkinson’s Disease

      • P. A. LeWitt
      Pages 289-299

    6. Alzheimer’s Disease and l-Deprenyl: Rationales and Findings

      • P. N. Tariot, L. S. Schneider, S. V. Patel, B. Goldstein
      Pages 301-317
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Editors and Affiliations

  • Dept. of Pharmacology, ASTA Medica AG, Frankfurt/Main 1, Germany

    I. Szelenyi

Bibliographic Information

  • Book Title: Inhibitors of Monoamine Oxidase B

  • Book Subtitle: Pharmacology and Clinical Use in Neurodegenerative Disorders

  • Editors: I. Szelenyi

  • Series Title: Milestones in Drug Therapy

  • DOI: https://doi.org/10.1007/978-3-0348-6348-3

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 1993

  • Softcover ISBN: 978-3-0348-6349-0Published: 11 April 2014

  • eBook ISBN: 978-3-0348-6348-3Published: 12 June 2019

  • Series ISSN: 2296-6056

  • Series E-ISSN: 2296-6064

  • Edition Number: 1

  • Number of Pages: XVIII, 367

  • Number of Illustrations: 41 b/w illustrations, 2 illustrations in colour

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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