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Proteins in Mycobacterium Tuberculosis

Functions and Therapeutic Advances

  • Book
  • Nov 2025

Overview

Authors:
  1. Parissa Farnia

    1. SBMU, Mycobacteriology Research Centre (MRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Tehran, Iran

  2. Ali Akbar Velayati

    1. SBMU, Mycobacteriology Research Centre (MRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Tehran, Iran

  3. Jalaledin Ghanavi

    1. SBMU, Mycobacteriology Research Centre (MRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Tehran, Iran

  4. Poopak Farnia

    1. SBMU, Mycobacteriology Research Centre (MRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Tehran, Iran

  • Provides a comprehensive overview of the most important functional proteins in M. tuberculosis
  • Explores the bacterium's survival strategies, pathogenicity, and resistance to treatment on a molecular level
  • Highlights latest methods in protein detection, analysis and characterization

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1484)

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About this book

This book presents an unprecedented exploration of the protein landscape and structural biology of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), a persistent global health crisis. It carefully differentiates Mtb proteins and their subclasses, along with associated byproducts, to deepen our understanding of the physiological variations within M. tuberculosis under diverse conditions and to drive the development of innovative treatment strategies.

Organized by the functional roles of proteins, the chapters reveal how individual proteins can perform multiple functions depending on the environmental context, highlighting the bacterium’s remarkable adaptability. The book systematically examines the contributions of surface and secreted proteins, metabolic enzymes, efflux pumps, pili, and proteins essential during both exponential growth and persistence phases of the Mtb life cycle. Special focus is given to novel protein targets involved in carbon, nitrogen, and iron–sulfur cluster assembly, as well as proteins with complex domain architectures known for their roles in immune modulation and antigenic variation. Additionally, it addresses protein alterations linked to drug resistance and discusses how structural dynamics and domain combinations influence resistance mechanisms and therapeutic vulnerabilities. By mapping these essential and species-specific proteins, the book emphasizes their potential as therapeutic targets to combat multidrug-resistant and extensively drug-resistant TB. It integrates computational, structural, and experimental approaches for protein target identification and validation, supporting the discovery of new inhibitors and combination therapies.

This comprehensive resource is invaluable for researchers, clinicians, and students in microbiology and infectious disease, offering foundational insights and cutting-edge research to guide future understanding of M. tuberculosis physiology under varying conditions and to inform novel treatment approaches.

Keywords

  • Proteins
  • Mycobacterium tuberculosis
  • Efflux Pumps
  • Tuberculosis Therapy
  • Mycobacterial Virulence
  • Drug Resistance
  • Mycobacterium Cell Biology

Authors and Affiliations

  • SBMU, Mycobacteriology Research Centre (MRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Tehran, Iran

    Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia

Accessibility Information

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This ebook is designed with accessibility in mind, aiming to meet the ePub Accessibility 1.0 AA and WCAG 2.2 Level AA standards. It features a navigable table of contents, structured headings, and alternative text for images, ensuring smooth, intuitive navigation and comprehension. The text is reflowable and resizable, with sufficient contrast. We recognize the importance of accessibility, and we welcome queries about accessibility for any of our products. If you have a question or an access need, please get in touch with us at accessibilitysupport@springernature.com.

Bibliographic Information

  • Book Title: Proteins in Mycobacterium Tuberculosis

  • Book Subtitle: Functions and Therapeutic Advances

  • Authors: Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia

  • Series Title: Advances in Experimental Medicine and Biology

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2026

  • Hardcover ISBN: 978-3-031-96882-2Due: 24 November 2025

  • Softcover ISBN: 978-3-031-96885-3Due: 24 November 2026

  • eBook ISBN: 978-3-031-96883-9Due: 24 November 2025

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: II, 411

  • Number of Illustrations: 1 b/w illustrations, 41 illustrations in colour

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