Extracellular Vesicles as Matrix Messengers

The cells in our body release a wide variety of factors into the extracellular space that help to signal, regulate and build the extracellular matrix. One of the most fascinating of these factors are extracellular vesicles (EVs). These lipid membrane-covered particles have now emerged as a new powerful method of near and distant intercellular communication. EVs facilitate communication between cells and their extracellular environment, which includes solid tissues and body fluids.

This volume summarizes current knowledge on EVs as integral and active components of the extracellular matrix. It covers topics such as the interplay between EVs and ECM molecules and how cancer cells modify their microenvironment by releasing EVs. Additionally, it discusses how EVs can mediate tissue repair and regeneration by modulating matrix degradation, protein cross-linking, and matrix calcification. The book explores instances where EVs play a crucial role in conditions related to matrix biology, such as cancer and arthritis, and considers their potential as therapeutic agents for these medical conditions.

Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and extracellular vesicles will find this book is an excellent introduction into the field of EV biology with applications in matrix research.

The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Kirsi Rilla, PhD, is a group leader at the Institute of Biomedicine, University of Eastern Finland. She received her M.Sc. degree in cell biology from the University of Jyväskylä (1998). Her Ph.D. project in the Tammi research group was focused on intracellular trafficking of hyaluronan synthases and regulation of their activity (2006). The thesis work led to the discovery of hyaluronan-dependent filopodia that act as hyaluronan factories. Especially intriguing is her finding that those filopodia act as platforms for extracellular vesicle shedding. Dr Rilla is experienced on the cellular and molecular mechanisms of cancer, extracellular matrix, hyaluronan and the biology of extracellular vesicles. During her research career, she has specifically focused on modern in vitro imaging techniques. Her current project is focused on extracellular vesicles, mechanism contributing to regulation of their secretion, interaction and effects on target cells and utilization of EVs as specific carriers of therapy.