Overview
- Covers the state-of-the-art methods and technologies
- Describes current and future approaches for the delivery of active pharmaceutical ingredients to the brain
- Discusses novel paradigms for the design of CNS therapeutics
Part of the book series: AAPS Introductions in the Pharmaceutical Sciences (AAPSINSTR, volume 9999)
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About this book
The book covers recent advances in the field of CNS therapeutics, including opportunities posed by expanding basic knowledge related to CNS conditions and novel approaches for efficient drug delivery to the brain (e.g., pharmaceutical nanocarriers and transporter- and transcytosis-mediated drug delivery to the brain inhibition of the blood-brain barrier). Chapters dealing with state-of-the-art in silico and in vitro tools for predictive purposes related to CNS bioavailability are also be included.
This is an ideal book for undergraduate students and graduates in the field of medicine and pharmaceutics, and professionals working in the field of brain disorders.
Keywords
- brain
- blood-brain-barrier
- nanomedicines
- brain bioavailability
- Transcytosis
- Blood-brain-barrier disruption
- central nervous systems
- drug delivery
- brain delivery
- in vitro blood-brain-barrier models
- Intranasal drug delivery
- Neuroinflammation
- Intranasal administration
- nanocarriers
- in silico CNS prediction
- CNS bioavailability
- Endocytosis
- Active targeting
- Brain inflammation
Editors and Affiliations
About the editor
Prof. Alan Talevi was born in Buenos Aires, 1980. He obtained his Pharmacy degree in 2004 and completed his PhD studies in 2007, both at the University of La Plata (UNLP, Argentina). Among other recognitions, he obtained the award for the best PhD thesis on Computational Chemistry from the Argentinean Chemical Society (2008), a Pacifichem Young Scholar Award (USA, 2010) and the Award to Scientific and Technological Production from UNLP (2016). Since 2010, he holds a permanent position at the Argentinean Council of Scientific and Technical Research (CONICET), where he currently occupies a Principal Researcher position, and he is a Full Professor (tenured) in charge of the Biopharmacy/Pharmacokinetics course at the Faculty of Exact Sciences, UNLP. He has published over 100 articles in periodicals and more than 80 book chapters/entries, mostly in the fields of machine learning, drug discovery and biopharmaceutics.
Bibliographic Information
Book Title: CNS Drug Development and Delivery
Book Subtitle: Concepts and Applications
Editors: Alan Talevi
Series Title: AAPS Introductions in the Pharmaceutical Sciences
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2024
Hardcover ISBN: 978-3-031-62603-6Due: 28 August 2024
Softcover ISBN: 978-3-031-62606-7Due: 28 August 2024
eBook ISBN: 978-3-031-62604-3Due: 28 August 2024
Series ISSN: 2522-834X
Series E-ISSN: 2522-8358
Edition Number: 1
Number of Pages: X, 222
Number of Illustrations: 2 b/w illustrations, 22 illustrations in colour