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Cytokine Storm Syndrome

  • Book
  • Jul 2024

Overview

Editors:
  1. Randy Q. Cron

    1. UAB School of Medicine, University of Alabama at Birmingham, Birmingham, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Edward M. Behrens

    1. Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides the fundamental basic and applied clinical science at the cutting edge of CSS treatment
  • Covers all aspects (clinical, genetics, pathophysiology, associations, therapy) as well as new research and advances
  • Updates and new coverage include novel genetics, new associated immune deficiencies, SARS-CoV-2, and treatment advances

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1448)

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Keywords

  • Hemophagocytic lymphohistiocytosis
  • Macrophage activation syndrome
  • Perforin
  • Cytolysis
  • Genetics
  • Cytokine Storm
  • cytogenetics
  • infectious diseases

About this book

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals.

A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This second edition addresses all aspects of the disorder, from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors and treatment. New-to-this-edition features include dedicated chapters on severe COVID-19 CSS, and post-COVID CSS of multi-system inflammatory syndrome in children (MIS-C). In addition, novel topics including CSS associated with Castleman disease, pregnancy, therapeutics, transplantation, and cardiac bypass, as well as treatment with JAK inhibitors are addressed. 

Editors and Affiliations

  • UAB School of Medicine, University of Alabama at Birmingham, Birmingham, USA

    Randy Q. Cron

  • Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA

    Edward M. Behrens

About the editors

Randy Q. Cron, MD, PhD,
University of Alabama at Birmingham
Professor of Pediatrics and Medicine
Birmingham, Alabama
USA


Edward M. Behrens, MD                 
University of Pennsylvania Perelman School of MedicinePerelman School of Medicine
Philadelphia, Pennsylvania
USA

Bibliographic Information

  • Book Title: Cytokine Storm Syndrome

  • Editors: Randy Q. Cron, Edward M. Behrens

  • Series Title: Advances in Experimental Medicine and Biology

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2024

  • Hardcover ISBN: 978-3-031-59814-2Due: 26 July 2024

  • Softcover ISBN: 978-3-031-59817-3Due: 26 July 2024

  • eBook ISBN: 978-3-031-59815-9Due: 26 July 2024

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 2

  • Number of Pages: XX, 600

  • Number of Illustrations: 10 b/w illustrations

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