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Microglia

Physiology, Pathophysiology and Therapeutic Potential

  • Book
  • Jul 2024
  • Latest edition

Overview

Editors:
  1. Marie-Ève Tremblay

    1. Division of Medical Sciences, University of Victoria, Victoria, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Alexei Verkhratsky

    1. Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Covers the role of microglia in the healthy brain as well as in pathological conditions
  • Presents the first comprehensive coverage of this hot topic
  • Features contributions from the major names in the field across 5 continents

Part of the book series: Advances in Neurobiology (NEUROBIOL, volume 37)

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Keywords

  • microglia
  • neurotrauma
  • neuropathic pain
  • neurodevelopmental disorders
  • neurosychiatric disorders
  • substance use and addiction
  • sleep disordres
  • neurodegenerative diseases
  • radiotracers
  • metabolites
  • immunometabolism
  • cell therapies

About this book

The past decade has witnessed a revolution in our understanding of microglia, especially since their roles in the healthy CNS have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their crucial involvement with diseases.  Edited by Drs. Marie-Ève Tremblay and Alexei Verkhratsky, Microglia: Physiology, Pathophysiology and Therapeutic Potential shares with the scientific and medical community the latest discoveries in the microglial research field, with a truly comprehensive collection of  chapters written by the top specialists across five continents. The book begins by explaining briefly what they are, from both historical and evolutionary points of view, and how they can be studied. The first section explains their physiological roles in the maturation, function, and plasticity of the CNS. The second section focuses on their general involvement in neuropathophysiology, and the third section on their critical implication in specific CNS diseases, including neurotrauma, neuropathic pain, ischemia and stroke, infectious diseases, autoimmune diseases, neurodevelopmental and neuropsychiatric disorders, substance use and addiction, sleep disorders, ageing, and neurodegenerative diseases. The fourth section presents their clinical potential as a targeted therapeutic tool for these  CNS diseases.


Editors and Affiliations

  • Division of Medical Sciences, University of Victoria, Victoria, Canada

    Marie-Ève Tremblay

  • Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

    Alexei Verkhratsky

About the editors

Marie-Eve Tremblay , Ph.D. is a Canada Research Chair (Tier II) in Neurobiology of Aging and Cognition, and an Associate Professor in the Division of Medical Sciences at the University of Victoria in Victoria, Canada. Her research findings have stimulated the development of a totally new field of research investigating the roles of microglia in the healthy brain. 

Alexei Verkhratsky, MD, Ph.D., DSc. is Professor of Neurophysiology in the Faculty of Biology, Medicine and Health at The University of Manchester in Manchester, England. Alexei Verkhratsky is an internationally recognized scholar in the field of cellular neurophysiology, best known for his contributions to our knowledge of the physiology and pathophysiology of neuroglia.

Bibliographic Information

  • Book Title: Microglia

  • Book Subtitle: Physiology, Pathophysiology and Therapeutic Potential

  • Editors: Marie-Ève Tremblay, Alexei Verkhratsky

  • Series Title: Advances in Neurobiology

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2024

  • Hardcover ISBN: 978-3-031-55528-2Due: 11 August 2024

  • Softcover ISBN: 978-3-031-55531-2Due: 11 August 2024

  • eBook ISBN: 978-3-031-55529-9Due: 11 August 2024

  • Series ISSN: 2190-5215

  • Series E-ISSN: 2190-5223

  • Edition Number: 1

  • Number of Illustrations: 100 illustrations in colour

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