Overview
- Describes in detail the development of the heart in health and disease
- Combines clinical and fundamental understanding on congenital heart diseases in a single volume
- Provides a state-of-the-art resource for both biomedical researchers and clinicians
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1441)
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Keywords
- cardiac malformation
- congenital heart disease
- genomics
- heart development
- molecular cardiology
- transcriptomics
- cardiac development
- genetic cardiac defects
About this book
This 2nd edition has been extensively updated and provides comprehensive and current insight into congenital heart diseases, from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways.
The book is divided into three parts: an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and insights from animal models and pathways. All chapters have been updated and new chapters added on state-of-the-art approaches including stem cells and organoids, cardiac metabolism, single cell transcriptomics and 3D reconstruction of human heart development. The clinical chapters have been extended and include new sections on diagnostic imaging techniques.
Taken together, the book, written by and for clinicians and researchers, provides an integrated and up-to-date resource for all those who want to learn more about both the clinical aspects and the genetic and molecular basis of congenital heart disease.
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Editors and Affiliations
About the editors
Silke Rickert-Sperling, MD, is Professor of Cardiovascular Genetics at the Charité – Universitätsmedizin Berlin and coopted professor at the Faculty of Biology, Chemistry and Pharmacy of the Freie Universität Berlin. She leads an interdisciplinary research group at the Experimental and Clinical Research Center of the Charité. Her research focuses on elucidating the molecular mechanisms as well as genetic parameters underlying cardiac development in health and disease.
Robert G. Kelly, PhD, is an Inserm Research Director at Aix Marseille University and a Group Leader in the Developmental Biology Institute of Marseilles. His groups´ research focuses on the cellular and molecular processes regulating development of cardiac progenitor cells, mouse models of congenital heart defects and the establishment of the ventricular conduction system.
Nikolaus Haas, MD, is Professor and Director of the Department of Pediatric Cardiology and Pediatric Intensive Care Medicine atthe LMU Klinikum in Munich. The main focuses of his clinical and scientific work are in the interventional treatment of congenital heart defects in all age groups, particularly newborns and premature infants. From 2020 to 2023, he served as President of the German Society for Pediatric Cardiology and Congenital Heart Defects e.V.
Bibliographic Information
Book Title: Congenital Heart Diseases: The Broken Heart
Book Subtitle: Clinical Features, Human Genetics and Molecular Pathways
Editors: Silke Rickert-Sperling, Robert G. Kelly, Nikolaus Haas
Series Title: Advances in Experimental Medicine and Biology
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2024
Hardcover ISBN: 978-3-031-44086-1Due: 11 June 2024
Softcover ISBN: 978-3-031-44089-2Due: 11 June 2024
eBook ISBN: 978-3-031-44087-8Due: 11 June 2024
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 2
Number of Pages: XXXIV, 1124