Overview
- Summarizes biological and chemical characteristics of oxy- and phyto-sterols
- Discusses the implication of oxysterol in aging and human disease
- Highlights the potential of oxysterols as biomarkers and their therapeutic application
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1440)
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Table of contents (22 chapters)
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Front Matter
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Bio- and Chemical- Synthesis, and Analytical Methods
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Front Matter
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Implication in Aging and Human Diseases
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Front Matter
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Biomarkers, Therapeutic and Industrial Applications
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Front Matter
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Keywords
About this book
This book provides basic knowledge of the biology, chemistry, and function of oxysterols and its derivatives as well as of phytosterols in numerous human diseases.
The book is divided into six sections and begins with an introduction to the biological and chemical properties of oxysterols and its derivatives as well as phytosterols, their synthesis, and the methods currently used for their detection in various biospecimens. The following section discusses in detail the various effects of oxysterols on numerous human diseases, including infectious diseases, inflammatory and autoimmune diseases, atherosclerosis, and cancer, as well as neurological and neuropsychiatric disorders. Importantly, the potential of oxysterols as biomarkers for some of these diseases is also highlighted. The book concludes with an outlook on the pharmacological and nutritional effects of oxysterols and phytosterols and their potential use by the food, and pharmaceutical industries.
Aiming to provide an in-depth overview of the biological and the chemical properties of oxysterols and phytosterols and their implications for human health, this book will be of interest to basic and clinical scientists, as well as to anyone working in the food or pharmaceutical industry who is exploring the potential of oxysterols and phytosterols.
Editors and Affiliations
About the editor
Gérard Lizard is an INSA-Lyon (France) biochemist engineer, PhD in Molecular and Cellular Biology and PhD in Human Biology. After a post-doc in pharmaceutical industry, he was recruited to INSERM in 1991 and since 2012 has been director of the Biochemistry Laboratory 'Peroxisome, Inflammation and Lipid Metabolism' at the University of Burgundy (Dijon, France). He was one of the first researchers to work on cell death by apoptosis associated with oxidative stress in the field of atherosclerosis, which led him to demonstrate that certain oxidized derivatives of cholesterol (oxysterols) induce a mode of cell death by oxiapoptophagy characterized by oxidative stress, apoptosis and autophagy. Gérard Lizard has gradually oriented his research on aging (biogerontology) and the pathophysiology of age-related diseases by focusing on the lipotoxicity of oxysterols and the impact on organelles (mitochondria, peroxisome). Gérard Lizard (Inserm Researcher) has been the director of 20 PhD theses and is the co-funding member of the European Network for Oxysterol Research (ENOR).
Bibliographic Information
Book Title: Implication of Oxysterols and Phytosterols in Aging and Human Diseases
Editors: Gérard Lizard
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-031-43883-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2024
Hardcover ISBN: 978-3-031-43882-0Published: 02 December 2023
Softcover ISBN: 978-3-031-43885-1Due: 15 April 2024
eBook ISBN: 978-3-031-43883-7Published: 01 December 2023
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XV, 462
Number of Illustrations: 15 b/w illustrations, 51 illustrations in colour
Topics: Cell Biology, Lipidology, Medical Biochemistry, Cancer Research, Immunology