Overview
- Uniquely summarizes current knowledge about the non-antimicrobial properties of the macrolide antibiotics
- Provides latest insight into their current use in treating inflammatory airway diseases
- Discusses potential use in treating other, non-pulmonary diseases
Part of the book series: Progress in Inflammation Research (PIR, volume 92)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (15 chapters)
-
Front Matter
-
Mechanisms of Action and Novel Macrolides
-
Front Matter
-
-
Clinical Use for Airway Disease
-
Front Matter
-
Keywords
- Macrolide antibiotics
- Infection
- Inflammation
- Immunomodulation
- Asthma
- Cystic fibrosis
- Inflammatory mediators
- Pediatric respiratory track infections
- Covid-19
- Rhinosinusitis
- Chronic obstructive pulmonary disease
- Antimicrobial resistance
- Transcription factors
- Extracellular Regulated Kinase
- Diffuse panbronchiolitis
- Epithelial barrier
- Neutrophil
About this book
For over 50 years, clinicians have known that macrolide antibiotics have effects on inflammation and the immune system that are not related to their antimicrobial properties. These immunomodulatory properties, best described for treating inflammatory airway diseases, protect the lung and the host and improve clinical status.
This book summarizes our current knowledge regarding proposed mechanisms for these properties, established clinical results, and what the future may hold with emphasis on novel clinical applications and the fascinating development of non-antimicrobial macrolides with preserved and enhanced immunomodulatory properties.
Editors and Affiliations
About the editors
Professor Bruce K. Rubin is the Jessie Ball duPont Distinguished Professor of Pediatrics and Biomedical Engineering at Virginia Commonwealth University. He trained in Biomedical Engineering at Oxford University on a Rhodes Scholarship and in Paediatric Respirology in Toronto. He holds the MD and MEngr degrees from Tulane and an MBA degree from Wake Forest University.
Prof. Rubin received the Forest Bird Lifetime Scientific Achievement Award and the Jimmy A Young Medal from the American Association for Respiratory Care, and he is a Prix Galien Laurate. He holds appointments in four medical schools, is on the editorial board of 10 journals, has published more than 300 original research papers and chapters (H-index 74) and holds 10 patents. His research focus is regulation of mucus clearance in health and disease, airway inflammation and immunomodulation, and aerosol delivery of medications.
Dr. Rubin is also a magician, a member of the International Brotherhood of Magicians (Wizard Award) and over the past 30 years has taught medical magic in 43 countries on 5 continents.
Dr. Masaharu Shinkai is the Vice Director of Tokyo Shinagawa Hospital and also the Director of the Clinical Trial Development & Research Center. He holds the MD from National Defense Medical College and a PhD degree from Yokohama City University. He has been involved in many respiratory clinical trials and drug development in Japan. In the last five years, he has been the principal investigator in 35 clinical trials, 22 of which have achieved FPI (First Patient In). He has about 100 articles on PubMed. Most recently, he has published 24 clinical and immunological papers on COVID-19 and its vaccines. His research focus is homeostasis, immunomodulation and mucus regulation in airway inflammation.
Bibliographic Information
Book Title: Macrolides as Immunomodulatory Agents
Editors: Bruce K. Rubin, Masaharu Shinkai
Series Title: Progress in Inflammation Research
DOI: https://doi.org/10.1007/978-3-031-42859-3
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2024
Hardcover ISBN: 978-3-031-42858-6Published: 05 January 2024
Softcover ISBN: 978-3-031-42861-6Due: 05 February 2024
eBook ISBN: 978-3-031-42859-3Published: 04 January 2024
Series ISSN: 1422-7746
Series E-ISSN: 2296-4525
Edition Number: 1
Number of Pages: VIII, 287
Number of Illustrations: 8 b/w illustrations, 10 illustrations in colour
Topics: Immunology, Cancer Research, Immunology, Immunology, Immunology