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Part of the book series: Progress in the Chemistry of Organic Natural Products (POGRCHEM, volume 123)
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Table of contents (1 chapter)
Keywords
About this book
This book deals with neurotrophins (NGF, BDNF, NT3, NT4), which can decrease cell death, induce differentiation, as well as sustain the structure and function of neurons. This makes neurotrophins potential therapeutic agents for the treatment of neurodegenerative disorders. However, these proteins have so far been ineffective in clinical trials mostly because they cannot pass the blood-brain barrier owing to their high-molecular weights. Consequently, small molecules that mimic neurotrophins and stimulate the synthesis of endogenous neurotrophins or enhance their neurotrophic actions are expected to be promising alternatives. Small-molecule natural products, which have been used in dietary functional foods or in traditional medicine over the course of human history, have potential to be developed as new therapeutic agents against neurodegenerative conditions such as Alzheimer’s disease. In this book, the authors introduce a variety of natural products possessing neurotrophic properties such as neurogenesis, neurite outgrowth promotion (neuritogenesis), and neuroprotection and focus on the chemistry and biology of several neurotrophic natural products.
Editors and Affiliations
About the editors
Bibliographic Information
Book Title: Neurotrophic Natural Products
Editors: A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, Verena M. Dirsch
Series Title: Progress in the Chemistry of Organic Natural Products
DOI: https://doi.org/10.1007/978-3-031-42422-9
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2024
Hardcover ISBN: 978-3-031-42421-2Published: 11 February 2024
Softcover ISBN: 978-3-031-42424-3Due: 13 March 2024
eBook ISBN: 978-3-031-42422-9Published: 10 February 2024
Series ISSN: 2191-7043
Series E-ISSN: 2192-4309
Edition Number: 1
Number of Pages: IX, 473
Number of Illustrations: 243 b/w illustrations, 54 illustrations in colour
Topics: Organic Chemistry, Biochemistry, general, Chemistry/Food Science, general, Neurochemistry